{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:27:22Z","timestamp":1754159242486,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Large B\u2010cell lymphomas (LBLs) comprise a genetically heterogeneous group of clinically aggressive non\u2010Hodgkin lymphomas, frequently exhibiting overlapping features with diffuse large B\u2010cell lymphoma and Burkitt's lymphoma. We report a case of a 24\u2010year\u2010old, previously healthy male with a classical clinical presentation of acute appendicitis. The pathologic examination discovered a <jats:italic>large B\u2010cell lymphoma with MYC and BCL6 rearrangements<\/jats:italic> in the excised appendix. The patient was assigned Stage IEA, IPI\u2009=\u20090 and received chemotherapy. This case depicts a very uncommon occurrence of fully localized LBL in a patient of an unusually young age and clinical presentation for this type of lymphoma.<\/jats:p>","DOI":"10.1111\/apm.13492","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T22:28:46Z","timestamp":1730845726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Localized large B\u2010cell lymphoma with MYC and BCL6 rearrangements as an unexpected finding in an appendectomy specimen"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6382-735X","authenticated-orcid":false,"given":"Przemyslaw Marcin","family":"Poltorak","sequence":"first","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine Lindhardt","family":"Plesner","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Stampe","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone","family":"Schejbel","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital Herlev  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Fredslund","family":"Breinholt","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital Herlev  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Lode","sequence":"additional","affiliation":[{"name":"Gastrounit, Surgical Section Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.08.079"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201001\u2010643569"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001620\u20102"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yamp.2022.06.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100609.2012.01787.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001577"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29781"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.06.006"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T03:53:58Z","timestamp":1753415638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/apm.13492"],"URL":"https:\/\/doi.org\/10.1111\/apm.13492","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"type":"print","value":"0903-4641"},{"type":"electronic","value":"1600-0463"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"2024-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13492"}}