{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:27:21Z","timestamp":1754159241499,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>The 2016 Amsterdam Placental Workshop Group Consensus Statement recommends sampling a block of the placenta close to the umbilical cord insertion site (UCIB) for histopathological evaluation. This piece of placenta at the umbilical cord insertion is presumed to give a better yield of inflammation (if present). We aimed to investigate the utility of the UCIB in the detection of maternal and\/or fetal inflammatory responses (MIR and\/or FIR), in comparison with the other sections of the placental parenchyma. This is a retrospective cross\u2010sectional study including all placentas with histologic chorioamnionitis. The histopathological slides of placentas were reviewed as per Amsterdam consensus guidelines. Diagnostic performance of UCIB in identifying MIR and\/or FIR, relative to the other placental sections, was assessed. UCIB revealed diagnostic sensitivity, specificity, and diagnostic accuracy of 79.2% (95% CI: 74.2\u201383.6%), 100.0% (95% CI: 95.6\u2013100.0%), and 83.6% (95% CI: 79.5\u201387.2%), respectively, in the detection of FIR, while showing a low sensitivity of 52.6% (95% CI: 47.5\u201357.6%) in detecting MIR. In 59 (24.6%) cases, FIR was not seen in the corresponding placental parenchymal sections but was detected in the UCIBs. This study is the first study to confirm that a section from the UCIB is essential for the detection of FIR, which affirms the Amsterdam consensus sampling recommendations.<\/jats:p>","DOI":"10.1111\/apm.13496","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T11:14:02Z","timestamp":1730978042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The value of umbilical cord insertion site sampling in detecting maternal and\/or fetal inflammatory response"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-9927","authenticated-orcid":false,"given":"Yin Ping","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Universiti Kebangsaan Malaysia  Kuala Lumpur Malaysia"},{"name":"Department of Pathology, SA Pathology Women's and Children's Hospital  North Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geok Chin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Universiti Kebangsaan Malaysia  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Yee","family":"Khong","sequence":"additional","affiliation":[{"name":"Department of Pathology, SA Pathology Women's and Children's Hospital  North Adelaide South Australia Australia"},{"name":"Department of Pathology, Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.17506"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2008.01.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00612"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.01.024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2019-0297"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.961009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.10.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01659.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/10935266221083776"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-7070-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2001.01284.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2350\/09-02-0604-OA.1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.55418\/9781933477091"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.13496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T03:53:53Z","timestamp":1753415633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.13496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/apm.13496"],"URL":"https:\/\/doi.org\/10.1111\/apm.13496","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"type":"print","value":"0903-4641"},{"type":"electronic","value":"1600-0463"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"2024-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13496"}}