{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:27:21Z","timestamp":1754159241408,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Resveratrol, which is thought to have a preventive effect on the formation of different types of cancer, is abundant in grapes and other foods. Resveratrol has been shown to have anti\u2010cancer effects by <jats:italic>in vitro<\/jats:italic> and<jats:italic>in vivo<\/jats:italic> studies, however this is the first time its effect on atypical acinar cell foci (AACF), known as precursor forms of pancreatic carcinoma, has been experimentally investigated. Male Sprague Dawley rats, each consisting of 5 experimental groups (Cont, AzCont, AzRes10, AzRes15, and AzRes20), 10 of which were 14\u2009days old, were used in the study. In the azaserine groups (AzCont, AzRes10, AzRes15, and AzRes20), it was investigated how the development of Atypical Cell Foci (AACF) resulting from intraperitoneal injection (i.p.) of azaserine (30\u2009mg\/kg bw) in 14\u2010day\u2010old rats was affected by dietary restoration. Male rats in the resveratrol group (AzRes10, AzRes15, and AzRes20) were fed diets containing 10%, 15%, or 20% mmol resveratrol for an 8\u2010month experimental period 1 week after the last azaserine injection. Pancreas preparations prepared from histological sections were examined for AACF burden and analyzed via a video image analyzer. One\u2010way analysis of variance (ANOVA) non\u2010parametric statistical analyses were performed to test whether there was a difference between the averages of the experimental and control groups. The AACF load in the azaserine group (AzCont) compared to the control group (Cont) was found to be statistically significant in all categories (p\u2009&lt;\u20090.05). The calculated estimated mean AACF volume (mm<jats:sup>3<\/jats:sup>) values and the AACF ratio as a percentage of the calculated organ volume were statistically significantly lower in all resveratrol groups (AzRes10, AzRes15, and AzRes20) compared to the azaserine control group (AzCont). The calculated estimated mean AACF volume (mm<jats:sup>3<\/jats:sup>) values and the AACF ratio as a percentage of the calculated organ volume were statistically significantly lower in all resveratrol groups (AzRes10, AzRes15, and AzRes20) compared to the azaserine control group (AzCont) (p\u2009&lt;\u20090.05). In addition, the calculated estimated mean AACF diameter (mm) in the AzRes10 and AzRes15 groups, in the AzRes15 group the calculated estimated mean AACF number in the whole organ and the calculated average AACF number per unit area were found to be statistically significant compared to the azaserine control group (AzCont) (p\u2009&lt;\u20090.05). According to the results of our study, it has been shown that atypical acinar cell foci (AACF) formed in the exocrine pancreas of rats with azaserine can be reduced by a diet containing resveratrol. It was determined that the tumor burden decreased statistically significantly (p\u2009\u2264\u20090.05) in resveratrol\u2010treated rats. Accordingly, it is thought that the inhibitory effects of resveratrol may contribute to studies that reduce the occurrence of pancreatic cancer.<\/jats:p>","DOI":"10.1111\/apm.13498","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T03:20:52Z","timestamp":1731381652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Possible inhibition effects of resveratrol on pancreatic tumorigenesis in the azaserine\u2010rat model"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-4005","authenticated-orcid":false,"given":"Hasan","family":"Y\u0131ld\u0131z","sequence":"first","affiliation":[{"name":"Biology Department, Faculty of Arts and Sciences Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-2963","authenticated-orcid":false,"given":"Serhat","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"General Surgery Department Private Kayseri Acibadem Hospital  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1801300923"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2101428"},{"key":"e_1_2_10_4_1","first-page":"306","article-title":"Update on pancreatic intraepithelialneoplasia","volume":"1","author":"Hruban RH","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62307-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.12.025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2060"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.07.021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.6.1844"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390802248627"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010022\u201000822\u2010z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025166"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200211000-00024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2010.05870.x"},{"key":"e_1_2_10_16_1","first-page":"2249","article-title":"Adenocarcinoma of the pancreas in azaserine\u2010rat\u2010treated rats","volume":"35","author":"Longnecker DS","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_10_17_1","first-page":"68","article-title":"Effect of pyridoxal deficiency on pancreatic DNA damage and nodule induction by azaserine","volume":"23","author":"Zurlo J","year":"1982","journal-title":"Proc Am Assoc Cancer Res"},{"key":"e_1_2_10_18_1","first-page":"141","article-title":"Characterization of two populations of pancreatic atypical acinar cell foci induced by azaserine in rat","volume":"50","author":"Roebuck BD","year":"1984","journal-title":"Lab Invest"},{"key":"e_1_2_10_19_1","unstructured":"\u00d6ztasH.The modulation of exocrine pancreatic carcinogenesis. 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