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We assessed the proportion of colistin\u2010resistant Gram\u2010negative isolates from intensive care unit (ICU) infections in different years, areas, pathogens, and antimicrobial susceptibility tests (AST). We searched the studies in PubMed, Scopus, Embase, and Web of Science (until November 2021). Statistical analyses were conducted using STATA software (ver. 14.0). The overall rate of colistin resistance was 5.18% (95% CI 2.70%\u20138.22%). The proportion of colistin resistance was 4% (95% CI 2%\u20137%) before 2015 and 6% (95% CI 4%\u20139%) in 2015\u20132019. The rates of colistin resistance in Europe, America, Asia, and Africa were 8.24%, 3.78%, 3.60%, and 0%, respectively. The proportion of colistin\u2010resistant non\u2010fermenting Gram\u2010negative bacilli isolated from the ICU was 2.25% (<jats:italic>Acinetobacter baumannii<\/jats:italic> [1.68%] and <jats:italic>Pseudomonas aeruginosa<\/jats:italic> [3.30%]). A 4\u2010fold increase in colistin resistance was observed when comparing EUCAST and CLSI. We described the global epidemiology of colistin resistance over time and shown the distribution of colistin\u2010resistant strains in different countries. Robust antimicrobial stewardship programs can increase the success of ICU physicians in improving patient outcomes.<\/jats:p>","DOI":"10.1111\/apm.13508","type":"journal-article","created":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T21:34:06Z","timestamp":1734903246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A systematic review and meta\u2010analysis: rising prevalence of colistin resistance in <scp>ICU<\/scp>\u2010acquired Gram\u2010negative bacteria"],"prefix":"10.1111","volume":"133","author":[{"given":"Na","family":"Li","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Headquarters Hospital of the Chinese People's Armed Police Force Zhejiang  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Medicine, Tehran University of Medical Sciences  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