{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:43:52Z","timestamp":1791233032513,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["Grant No: 20884\u201000"],"award-info":[{"award-number":["Grant No: 20884\u201000"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006402","name":"Fasa University of Medical Sciences","doi-asserted-by":"publisher","award":["Grant No: 97444"],"award-info":[{"award-number":["Grant No: 97444"]}],"id":[{"id":"10.13039\/501100006402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Tumor\u2010associated antigens that can induce antitumor immune responses as well as endogenous microRNAs are found in tumor\u2010derived exosomes (TEXs). The objective of the current investigation was to assess the ability of MicroRNA (miR)\u2010211\u2010enriched TEX (TEXomiR) to induce antitumor immune responses in a melanoma mouse model. B16F10 melanoma cells in culture were used to extract exosomes. MiR\u2010211 mimics were introduced into the exosomes using a modified calcium chloride technique. In C57BL\/6 mice, the effects of TEXomiR were assessed by measuring tumor growth, weight, immune cell populations in the tumor and spleen and cytokine release. PBS, TEX, or TEXomiR were given subcutaneously to mice three times every 3\u2009days until tumors grew to a size of 100\u2009mm<jats:sup>3<\/jats:sup>. In\u00a0vivo experiments using B16F10\u2010bearing mice indicated that, in comparison with unmodified TEX and PBS, TEXomiR administration boosted improved antitumor immune responses. There was a notable increase in survival time. Mice treated with TEXomiR showed suppression of tumor development. Tumor tissue had much lower ratios of T regularity\/CD8 T cells and CD4\/CD8 T cells. Our findings showed that TEXomiR stimulates antitumor immune responses and that tumor\u2010derived exosomes are an effective vehicle for miR\u2010211 mimic delivery.<\/jats:p>","DOI":"10.1111\/apm.13512","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T02:44:32Z","timestamp":1745808272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tumor\u2010Derived Exosomes Enriched by <scp>miRNA<\/scp>\u2010211a Promote Antitumor Immune Response in <scp>B16F10<\/scp> Tumor\u2010Bearing Mice"],"prefix":"10.1111","volume":"133","author":[{"given":"Mohammad Reza","family":"Ataollahi","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Atashzar","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Ghanbari","family":"Asad","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi Mokhtari","family":"Tabar","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-4484","authenticated-orcid":false,"given":"Davar","family":"Amani","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.17998\/jlc.21.1.92"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.6001\/actamedica.v24i1.3460"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01394-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020415"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065386"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165648"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010201"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.628367"},{"issue":"4","key":"e_1_2_10_12_1","first-page":"1659","article-title":"The Expression of miR\u2010211 in Cutaneous Melanoma and the Effect of Its Overexpression on the Proliferation and Migration of A375 Melanoma Cells and on VEGF Expression","volume":"14","author":"Xin N.","year":"2021","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2016.05.017"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2023.2217843"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486814"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00849.x"},{"issue":"7","key":"e_1_2_10_17_1","first-page":"1","article-title":"BRN2 Expression Increases Anoikis Resistance in Melanoma","volume":"9","author":"Pierce C. 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