{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:18:22Z","timestamp":1792444702785,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study prospectively collected the clinical data, information on respiratory pathogens, and laboratory findings of children with <jats:styled-content style=\"fixed-case\"><jats:italic>Mycoplasma pneumoniae<\/jats:italic><\/jats:styled-content> (<jats:italic>M. pneumonia<\/jats:italic>) infection who were hospitalized at the First Affiliated Hospital of Anhui Medical University during the <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> outbreak in Hefei City, Anhui Province, China, between October 2023 and December 2023. We analyzed the prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> infection in hospitalized children during the <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> outbreak, discrepancies in the detection of <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> by multiplex polymerase chain reaction (PCR) and serological methods, and the differences in clinical characteristics and laboratory results of patients with co\u2010infections of <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> and other pathogens with the aim of providing a reference for disease assessment and clinical treatment of <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content>. A total of 270 children, 146 males and 124 females, were enrolled in the study after screening with the inclusion criteria. The most common co\u2010infections were adenovirus (ADV) (48 cases) and influenza A virus (FLU A) (30 cases). The prevalence of infections was higher in children under the age of 7\u2009years (54.1%). In addition, 167 of the PCR\u2010positive patients were infected with macrolide\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>Mycoplasma pneumoniae<\/jats:italic><\/jats:styled-content> (MRMP), suggesting that MRMP infections are common in hospitalized children. Levels of procalcitonin (PCT) (OR 15.765 [95% CI, 1.651\u2013150.533], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.017) and lactate dehydrogenase (LDH) (OR 1.006 [95% CI, 1.003\u20131.009], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were independently predictive of co\u2010infections in patients infected with <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.13514","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T04:45:37Z","timestamp":1736484337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Laboratory Diagnoses of Pediatric Patients Hospitalized During an Outbreak of <scp><i>Mycoplasma pneumoniae<\/i><\/scp>"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3538-308X","authenticated-orcid":false,"given":"Tao","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-3800","authenticated-orcid":false,"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"issue":"12","key":"e_1_2_11_2_1","first-page":"916","article-title":"Mycoplasma pneumoniae\n                   Macrolide Resistance and MLVA Typing in Children in Beijing, China, in 2016: Is It Relevant?","volume":"33","author":"Dou H. 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