{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:24:49Z","timestamp":1753878289323,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Laryngeal squamous cell carcinoma (LSCC) is characterized by diverse profiles of tumor\u2010infiltrating lymphocytes (TILs). We aimed to investigate the potential prognostic role of TILs and programmed death\u2010ligand 1 (PD\u2010L1) in patients with supraglottic LSCC. The expression of PD\u2010L1 and TILs was assessed using immunohistochemistry in 39 patients with primary supraglottic LSCC and correlated with clinicopathological characteristics and disease\u2010free survival (DFS). Survival curves were measured using the Kaplan\u2013Meier method, and differences in survival between the groups were estimated using the log\u2010rank test. TIL density was significantly higher in PD\u2010L1\u2010positive (combined positive score: CPS\u2009\u2265\u20091) than in PD\u2010L1\u2010negative (CPS\u2009&lt;\u20091) patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.000). Lower PD\u2010L1 expression was significantly associated with a locoregional recurrence (Fisher's exact test, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). DFS was significantly longer in patients with CPS\u2009\u2265\u20091 than in those with CPS\u2009&lt;\u20091 (Log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Multivariate Cox regression analysis showed that a low CPS (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and positive nodal status (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) were statistically significant and independent predictors of malignancy recurrence. PD\u2010L1 represents a valuable marker for predicting recurrence and shorter survival after definitive therapy.<\/jats:p>","DOI":"10.1111\/apm.70005","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T09:00:07Z","timestamp":1739782807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Prognostic Significance of <scp>PD<\/scp>\u2010<scp>L1<\/scp> Expression and Associated Tumor\u2010Infiltrating Lymphocytes in Supraglottic Laryngeal Squamous Cell Carcinoma"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-0849","authenticated-orcid":false,"given":"Elvir","family":"Zvrko","sequence":"first","affiliation":[{"name":"Clinical Center of Montenegro  Podgorica Montenegro"},{"name":"University of Montenegro  Podgorica Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhedin","family":"Kadic","sequence":"additional","affiliation":[{"name":"Clinical Center of Montenegro  Podgorica Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Vuckovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Montenegro  Podgorica Montenegro"},{"name":"University of Montenegro  Podgorica Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"volume-title":"World Cancer Report: Cancer Research for Cancer Prevention","year":"2020","author":"Wild C. 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