{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:04:12Z","timestamp":1788519852126,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Protein\u2010energy wasting (PEW) facilitates major adverse clinical outcomes in chronic renal failure (CRF), with current therapies not suitable for all patients. <jats:styled-content style=\"fixed-case\"><jats:italic>Faecalibacterium prausnitzii<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>F. prausnitzii<\/jats:italic><\/jats:styled-content>) can alleviate chronic kidney disease, with unclear effects and mechanisms on CRF with PEW. The CRF rat model was constructed by adenine administration, and PEW was induced by a 4% casein diet. The serum creatinine (SCR), urinary protein (UPR), and blood urea nitrogen (BUN) levels were measured by enzyme\u2010linked immunosorbent assay. Pathology of the gastrocnemius muscle was estimated using hematoxylin and eosin staining. The expression of mitophagy\u2010related markers was detected to assess the mitophagy level. Dexamethasone\u2010induced L6 myotubes established myotube atrophy models. The levels of mitophagy\u2010related markers, muscle RING\u2010finger protein\u20101 (MuRF1), and atrophy gene 1 (Atrogin1) were detected by quantitative reverse transcription\u2010polymerase chain reaction and western blotting. <jats:styled-content style=\"fixed-case\"><jats:italic>F. prausnitzii<\/jats:italic><\/jats:styled-content> suppressed the SCR, UPR, and BUN expression in serum and gastrocnemius muscle atrophy, which were promoted by CRF with PEW. Dexamethasone\u2010induced expression of MuRF1 and Atrogin1 in L6 myotubes was decreased by <jats:styled-content style=\"fixed-case\"><jats:italic>F. prausnitzii<\/jats:italic><\/jats:styled-content>. Additionally, <jats:styled-content style=\"fixed-case\"><jats:italic>F. prausnitzii<\/jats:italic><\/jats:styled-content> repressed mitophagy in the gastrocnemius muscle and L6 myotubes. In conclusion,\u00a0<jats:styled-content style=\"fixed-case\"><jats:italic>F. prausnitzii<\/jats:italic><\/jats:styled-content> suppressed renal failure progression and muscle atrophy by inhibiting mitophagy in CRF with PEW.<\/jats:p>","DOI":"10.1111\/apm.70014","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:32:46Z","timestamp":1741743166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Faecalibacterium prausnitzii<\/i> Suppresses Mitophagy to Alleviate Muscle Atrophy in Chronic Renal Failure With Protein\u2010Energy Wasting"],"prefix":"10.1111","volume":"133","author":[{"given":"Jingwen","family":"Ni","sequence":"first","affiliation":[{"name":"Guangdong Medical University  Zhanjiang Guangdong China"},{"name":"Department of Nephrology Guangzhou Red Cross Hospital, Jinan University  Guangzhou Guangdong 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