{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:38Z","timestamp":1787013878893,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatocellular carcinoma (HCC) is a major cause of cancer\u2010related deaths worldwide. Aurora kinase B (AURKB), a critical regulator of mitosis, has been implicated in cancer progression, though its precise role in HCC remains unclear. In this study, AURKB expression was found to be significantly elevated in HCC tissues and cell lines compared to controls, as validated by GEPIA and ENCORI databases. Functional assays revealed that AURKB knockdown reduced cell proliferation, invasion, and migration, while increasing apoptosis. Furthermore, suppression of AURKB affected epithelial\u2010mesenchymal transition (EMT) markers, decreasing vimentin and N\u2010cadherin levels and increasing E\u2010cadherin expression. In\u00a0vivo, a xenograft mouse model demonstrated that tumors derived from AURKB\u2010silenced cells exhibited reduced growth and fewer lung metastases. Histological and immunohistochemical analyses showed lower levels of Ki\u201067, MMP\u20109, and EMT markers in these tumors, alongside increased E\u2010cadherin. These findings highlight AURKB's critical role in promoting HCC progression, metastasis, and EMT regulation. Overexpression of AURKB was associated with poor prognosis, suggesting it could serve as a potential biomarker and therapeutic target for liver cancer. Overall, targeting AURKB may provide a novel approach to inhibit HCC growth and metastasis, improving patient outcomes.<\/jats:p>","DOI":"10.1111\/apm.70021","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T18:39:03Z","timestamp":1743791943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["AURKB as a Therapeutic Target and Key Driver of Liver Cancer Growth and Metastasis"],"prefix":"10.1111","volume":"133","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Interventional Vascular The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6757-3708","authenticated-orcid":false,"given":"Jiangwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobilary Surgery The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Insurance Office The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Medical The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Catheterization Room The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hepatobilary Surgery The Third Affiliated Hospital of Xinjiang Shihezi University  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030666"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050901"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.18"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12345"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2019.188314"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-090514-013832"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12316"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14893"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1245"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.14"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2021.108376"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-018-0048-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05539-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.07.006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00426-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05099-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-022-00337-w"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-024-02584-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2023.2181162"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-023-10084-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205605"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116691"},{"key":"e_1_2_9_24_1","first-page":"8019","article-title":"AURKB Promotes Colorectal Cancer Progression by Triggering the Phosphorylation of Histone H3 at Serine 10 to Activate CCNE1 Expression","volume":"16","author":"Li L.","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042199"},{"key":"e_1_2_9_26_1","first-page":"341","article-title":"Role of AURKB Inhibition in Reducing Proliferation and Enhancing Effects of Radiotherapy in Triple\u2010Negative Breast Cancer","volume":"16","author":"Pellizzari S.","year":"2024","journal-title":"Breast Cancer (Dove Medical Press)"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2012.12.018"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00707-1"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S254250"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-1165-z"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23775"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7718"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01305-3"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000718"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq344"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28083385"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201016\u20100298"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.70021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T04:19:29Z","timestamp":1755490769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.70021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/apm.70021"],"URL":"https:\/\/doi.org\/10.1111\/apm.70021","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70021"}}