{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:51:05Z","timestamp":1772211065029,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>MicroRNA (miRNA) shows promise as a biomarker for sepsis diagnosis and prognosis. In the present investigation, we examined the potential of miR\u2010181a\u20105p as a clinical diagnostic and prognostic indicator for sepsis. This study enrolled 119 sepsis patients and 125 controls. Serum miR\u2010181a\u20105p levels were assessed via RT\u2010qPCR, revealing a significant upregulation in sepsis patients. The receiver operating characteristic (ROC) curve indicated miR\u2010181a\u20105p could distinguish sepsis patients with 73.11% sensitivity and 89.60% specificity (AUC\u2009=\u20090.879). Pearson's analysis showed serum miR\u2010181a\u20105p positively correlated with disease severity scores (APACHE II and SOFA), procalcitonin (PCT), C\u2010reactive protein (CRP), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin 6 (IL\u20106), malondialdehyde (MDA), and negative with glutathione peroxidase (GSH\u2010Px). Kaplan\u2013Meier survival analysis revealed that elevated serum miR\u2010181a\u20105p levels were associated with a worse 28\u2010day prognosis in sepsis patients (log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.022). In summary, this study identifies serum miR\u2010181a\u20105p as a diagnostic and prognostic biomarker for sepsis, significantly linked to disease severity, inflammation, and oxidative stress, providing new avenues for sepsis management.<\/jats:p>","DOI":"10.1111\/apm.70037","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:33:39Z","timestamp":1750732419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum <scp>miR<\/scp>\u2010181a\u20105p Serves as a Diagnostic Biomarker for Sepsis and Predicts Clinical Outcomes"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2217-4331","authenticated-orcid":false,"given":"Huibo","family":"Li","sequence":"first","affiliation":[{"name":"Emergency Department Gulou Hospital of Traditional Chinese Medicine of Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Emergency Department, Guang'anmen Hospital China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Luo","sequence":"additional","affiliation":[{"name":"Emergency Department Gulou Hospital of Traditional Chinese Medicine of Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangzhe","family":"Ni","sequence":"additional","affiliation":[{"name":"Emergency Department Gulou Hospital of Traditional Chinese Medicine of Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Emergency Department Gulou Hospital of Traditional Chinese Medicine of Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyun","family":"Chu","sequence":"additional","affiliation":[{"name":"Emergency Department Gulou Hospital of Traditional Chinese Medicine of Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[{"name":"Emergency Department Gulou Hospital of Traditional Chinese Medicine of Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0179"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13463"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2025.152870"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04385-x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89946-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01321"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.034"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13512"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"293","article-title":"MiR\u2010181a\u20105p Inhibits Uveal Melanoma Development by Targeting GNAQ and AKT3","volume":"13","author":"Wang R.","year":"2023","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02381"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.029"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S323433"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23151"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101199"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1056903"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.03.025"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133324"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105933"},{"issue":"2","key":"e_1_2_10_23_1","first-page":"231","article-title":"Long Non\u2010Coding RNA Small Nucleolar RNA Host Gene 1 Alleviates Sepsis\u2010Associated Myocardial Injury by Modulating the miR\u2010181a\u20105p\/XIAP Axis In\u00a0Vitro","volume":"51","author":"Luo S.","year":"2021","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.949675"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-022-00422-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00765-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3587-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.70030"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.01.020"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1139\/gen-2022-0040"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11365-5"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000209"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/med-2019-0106"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-4910-6"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.741268"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_1504_21"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.853818"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics9020045"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.07.019"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13787"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1509496"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-81860-7"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10332"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425919880946"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T09:23:26Z","timestamp":1750929806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/apm.70037"],"URL":"https:\/\/doi.org\/10.1111\/apm.70037","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70037"}}