{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:09:53Z","timestamp":1777115393807,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Hematogenous prosthetic joint infections (PJIs) are primarily associated with\n \n Staphylococcus aureus<\/jats:italic>\n <\/jats:styled-content>\n , and there is a 30%\u201340% risk of contracting a hematogenous PJI following an\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n bacteremia. The aim of this study was to investigate whether identical strains of\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n were present in each patient from a cohort with both bacteremia and PJI and to explore the genomic differences between paired isolates obtained from blood cultures and tissue biopsies. All patients with a PJI and a temporally concomitant bacteremia due to\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n from 2005 to 2020 were included. Paired isolates of\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n from tissue biopsies and blood cultures were subjected to whole\u2010genome sequencing. Twenty\u2010four episodes of PJI were identified in 23 patients. All pairwise isolates from individual patients belonged to the same multilocus sequence type, clonal complex, and core genome multilocus sequence typing (cgMLST) complex type. The median number of single nucleotide polymorphisms (SNPs) in the conserved core genomes between the pairwise isolates was 3. In conclusion, identical cgMLST complex types and low levels of SNP differences between paired isolates of\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n from blood cultures and tissue biopsies suggest hematogenous seeding in all cases of PJI in this cohort.\n <\/jats:p>","DOI":"10.1111\/apm.70038","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T02:25:26Z","timestamp":1751595926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Staphylococcus aureus<\/i>\n From Prosthetic Joint Infections and Blood Cultures Display the Same Genetic Background"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-2932","authenticated-orcid":false,"given":"Bo","family":"S\u00f6derquist","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Orthopedics, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Laboratory Medicine, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wildeman","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Orthopedics, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Stegger","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Bioinformatics Statens Serum Institut Copenhagen Denmark"},{"name":"Antimicrobial Resistance and Infectious Diseases Laboratory Harry Butler Institute, Murdoch University Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Stenmark","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Laboratory Medicine, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"3","article-title":"Similar Periprosthetic Joint Infection Rates After and Before a National Infection Control Program: A Study of 45,438 Primary Total Knee Arthroplasties","volume":"93","author":"Thompson O.","year":"2022","journal-title":"Acta 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