{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:14:23Z","timestamp":1788880463129,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The aim of this study is to explore the correlation between the levels of miR\u2010222\u20103p and the onset of acute pancreatitis (AP) and further verify the role of miR\u2010222\u20103p in the pathogenesis of AP through targeted regulation of Sirtuin 1 (SIRT1). This study encompassed a total of 160 AP patients, including 80 patients with mild and moderate AP (non\u2010SAP) and 80 patients with severe AP (SAP). The levels of miR\u2010222\u20103p and SIRT1 were detected by reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR) technology, and the potential significance of miR\u2010222\u20103p in the diagnosis of AP was evaluated by receiver operating characteristic curve. The proliferation activity of cerulein\u2010induced HPDE6\u2010C7 cells was investigated by Cell Counting Kit\u20108 method. Meanwhile, the changes in the levels of inflammatory factors were quantified using enzyme\u2010linked immunosorbent assay (ELISA) kits. The result showed that miR\u2010222\u20103p was elevated in AP patients, especially in SAP patients. Elevated miR\u2010222\u20103p levels showed diagnostic significance for AP. Inhibiting miR\u2010222\u20103p promoted the proliferation of cerulein\u2010damaged HPDE6\u2010C7 cells and reduced inflammatory factor increases induced by cerulein. SIRT1 inhibition reversed the effects of miR\u2010222\u20103p on cerulein\u2010induced HPDE6\u2010C7 cells. Inhibition of miR\u2010222\u20103p may alleviate the development of AP by targeting SIRT1.<\/jats:p>","DOI":"10.1111\/apm.70043","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T03:29:53Z","timestamp":1751599793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of mi\n                    <scp>R<\/scp>\n                    \u2010222\u20103p Alleviates Acute Pancreatitis by Negatively Regulating the Expression of\n                    <scp>SIRT<\/scp>\n                    1"],"prefix":"10.1111","volume":"133","author":[{"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery PLA Rocket Force Characteristic Medical Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endocrinology The 9th Hospital of Wuhan  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7247-7250","authenticated-orcid":false,"given":"Wenzhao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine 923 Hospital, Joint Support Force  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400803RR"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103959"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01766-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00726"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S384068"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12666"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2020-0084"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2022.21769"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417449"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03185-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70400"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-022-09736-y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111058"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.08.022"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06331-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207326666230803140408"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2022.68.9.17"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.2014653"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S372420"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2014.03.019"},{"key":"e_1_2_9_22_1","first-page":"26","article-title":"Assessment of Acute Pancreatitis Severity via Determination of Serum Levels of Hsa\u2010miR\u2010126\u20105p and IL\u20106","volume":"21","author":"Chen Y. 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