{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:30:41Z","timestamp":1765269041811,"version":"3.44.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cystic fibrosis (CF) is commonly associated with musculoskeletal issues including inflammatory arthritis, CF arthritis. We present a retrospective cohort study which aims to describe the clinical characteristics, prevalence, and demographic associations of CF arthritis using both a clinical and literature cohort. We identified adult CF patients (\u2265\u200918\u2009years) with arthritis from the rheumatology clinic at Rigshospitalet (2020\u20132022). The clinical cohort (CC) was reviewed through electronic medical records. Literature cases were identified by searching online databases for relevant studies, case reports, and reviews on CF arthritis. Eleven CF patients with arthritis were identified (CC) from our clinic and 54 cases from the literature (literature cohort, LC). Both cohorts showed equal gender distribution. In the LC, arthritis onset had a median age of 11\u2009years (range 2\u201328), while in the CC it was 26\u2009years (range 13\u201343). Clinical features were similar in both cohorts: the majority had episodic relapsing arthritis, with two\u2010thirds having mono\u2010\/oligoarthritis and one\u2010third polyarthritis. Large joints were most commonly affected. No clear link to pulmonary disease or serologic markers was found. Immunosuppressive treatment was safe. CF arthritis is a heterogeneous condition, presenting as non\u2010erosive, episodic oligo\u2010 or polyarthritis affecting both large and small joints.<\/jats:p>","DOI":"10.1111\/apm.70058","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:38:52Z","timestamp":1754383132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Arthritis in Cystic Fibrosis\u2014Comparison of a Single\u2010Center Cohort and Published Case Reports\/Series and a Review of the Literature"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-6051","authenticated-orcid":false,"given":"Anne Sofie Rosenborg","family":"Peretz","sequence":"first","affiliation":[{"name":"Center for Rheumatology and Spine Diseases University Hospital \u2013 Rigshospitalet  Frederiksberg Denmark"},{"name":"Copenhagen Research Center for Autoimmune Connective Tissue Diseases (COPEACT) Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-6766","authenticated-orcid":false,"given":"Thomas","family":"Bryrup","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center Copenhagen, Department of Infectious Diseases Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Faurholt\u2010Jepsen","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center Copenhagen, Department of Infectious Diseases Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoffer Tandrup Holst","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Copenhagen Research Center for Autoimmune Connective Tissue Diseases (COPEACT) Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12567-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/DUUVFR11W595V7FE"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"651","article-title":"Episodic Arthropathy in Adult Cystic Fibrosis","volume":"64","author":"Bourke S.","year":"1987","journal-title":"QJM: An International Journal of Medicine"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80018-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.3.218"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-234305"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2015.1122834"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.01.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-012-9393-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.12.022"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1258\/JRSM.2011.S11106"},{"issue":"9","key":"e_1_2_8_13_1","first-page":"1882","article-title":"Musculoskeletal Manifestations and Rheumatic Symptoms in Patients With Cystic Fibrosis (CF) no Observations of CF\u2010Specific Arthropathy","volume":"35","author":"Koch A. 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