{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:10:05Z","timestamp":1756203005426,"version":"3.44.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aims to examine the relationship between the subcarinal angle (SCA) and the risk and severity of parenchymal involvement in COVID\u201019 positive patients. This retrospective study involved 2006 patients, categorized into a study group of 1003 COVID\u201019 positive patients with parenchymal involvement and a control group of 1003 patients with COVID\u201019\u2010like symptoms but without parenchymal involvement. Receiver Operating Characteristic (ROC) analysis was used to establish cut\u2010off values for SCA and age that predict disease progression and severity. The study and control groups had mean ages of 51.80 and 45.76\u2009years, respectively. Males had a higher frequency of parenchymal involvement (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). ROC analysis identified SCA cut\u2010offs of 34.5\u00b0\u201335.5\u00b0 for the right SCA, 39.5\u00b0\u201340.5\u00b0 for the left SCA, and 74.5\u00b0\u201375.5\u00b0 for the total SCA. Age cut\u2010offs were set at 47\u2009years for increased risk and 54\u2009years for greater severity of involvement. SCA values above 36\u00b0 for the right, 42\u00b0 for the left, and 77\u00b0 for the total significantly increased the Tomographic Severity Score (TSS), indicating more severe disease. The TSS was higher in males and positively correlated with age and SCA, suggesting that both factors are important in predicting the severity of COVID\u201019 pneumonia. SCA is a key predictor of the severity and extent of COVID\u201019 pneumonia. Measuring SCA alongside age can enhance early risk assessment, disease management, and the implementation of timely and effective interventions, potentially reducing the morbidity and mortality associated with the disease.<\/jats:p>","DOI":"10.1111\/apm.70062","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T02:35:34Z","timestamp":1755138934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Subcarinal Angle on Parenchymal Involvement and Disease Severity in <scp>COVID<\/scp>\u201019 Pneumonia: A Retrospective Analysis"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-4050","authenticated-orcid":false,"given":"Seda","family":"Akyol","sequence":"first","affiliation":[{"name":"Department of Radiology, Memorial Ankara Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-1412","authenticated-orcid":false,"given":"\u00d6nder","family":"Eraslan","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine, Usk\u00fcdar University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596\u2010021\u20102395\u20101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag\u20102004\u2010331"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2303030853"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00527.2002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.01109s4523"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4209\/aaqr.2018.09.0343"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.18678\/dtfd.1021421"},{"issue":"16","key":"e_1_2_9_9_1","first-page":"3351","article-title":"Age and Gender Related Changes in Bronchial Tree: A Morphometric Study With Multidedector CT","volume":"20","author":"Ulusoy M.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123177"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20815"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v15.i4.118"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4274\/tybd.galenos.2020.29292"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055\u2010021\u201000408\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320\u20106012.ijrms20191526"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400020065014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010021\u201001798\u20106"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T09:39:00Z","timestamp":1756201140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/apm.70062"],"URL":"https:\/\/doi.org\/10.1111\/apm.70062","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2024-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"}}