{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:02Z","timestamp":1784869322894,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/001637"],"award-info":[{"award-number":["EMR\/2017\/001637"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) infection leads to gastric carcinoma (GC), while aurora kinase A (AURKA) is known to be upregulated in several cancers. However, the direct association between AURKA and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    remains largely unexplored. The significance of AURKA in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection was investigated using an RNAi\u2010mediated silencing method. The expression of downstream signaling genes and apoptotic markers was analyzed through qRT\u2010PCR and western blot. Cancerous properties were evaluated through scratch wound assay, cell counting through trypan blue, and genomic instability assay. We used RNAi\u2010mediated gene silencing to knock down AURKA expression and observed a reduction in the transcript levels of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    pathogenic genes, signaling genes associated with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection. We found that AURKA regulated STAT3 and c\u2010Myc, which further enhanced the oncogenic potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Moreover, AURKA knockdown led to the activation of apoptotic markers and alterations in mitochondrial biomass and membrane potential during\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">H.<\/jats:styled-content>\n                      pylori\n                    <\/jats:italic>\n                    infection. Additionally, AURKA knockdown reduced cell proliferation, migration, and genomic instability in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010infected AGS cells. This study demonstrates that AURKA knockdown could abrogate\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010induced expression of STAT3 and c\u2010Myc in AGS, suggesting a functional signaling axis linking AURKA to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010mediated downstream effects.\n                  <\/jats:p>","DOI":"10.1111\/apm.70077","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T08:01:25Z","timestamp":1760083285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aurora Kinase A: The Prominent Oncogenic Link in\n                    <i>Helicobacter pylori<\/i>\n        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