{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:28:14Z","timestamp":1792106894398,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      End\u2010stage renal disease (ESRD) threatens human lives due to the high incidence rate of complications. Vascular calcification is a severe complication of ESRD inducing major adverse cardiovascular events (MACEs). This study enrolled 205 patients diagnosed with chronic kidney disease (CKD), including 95 patients diagnosed at end stages. The clinical significance of miR\u2010378a\u20103p was assessed from the perspectives of early screening, risk prediction, and MACE prediction. The regulation of vascular calcification by miR\u2010378a\u20103p was estimated through inflammation, osteogenic differentiation, Ca\n                      <jats:sup>2+<\/jats:sup>\n                      concentration, and cell proliferation in human vascular smooth muscle cells (hVSMCs). Significant downregulation of miR\u2010378a\u20103p was observed in ESRD patients, which discriminated ESRD patients from early\u2010stage CKD patients and predicted the risk of ESRD. Lower serum miR\u2010378a\u20103p levels were observed in ESRD patients developing vascular calcification and were identified as a risk factor for the occurrence of MACEs. Overexpression of miR\u2010378a\u20103p could alleviate calcified culture medium\u2010induced inflammation, osteogenic differentiation, increasing Ca\n                      <jats:sup>2+<\/jats:sup>\n                      , and decreasing cell proliferation of hVSMCs. SULF1 was negatively regulated by miR\u2010378a\u20103p. The overexpression of SULF1 reversed the protective effect of miR\u2010378a\u20103p on vascular calcification. miR\u2010378a\u20103p acted as a biomarker for screening ESRD and predicting adverse outcomes of patients. miR\u2010378a\u20103p regulated vascular calcification through targeting SULF1.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apm.70097","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:29:30Z","timestamp":1765438170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circulating miR\u2010378a\u20103p Screens End\u2010Stage Renal Disease Patients, Predicts the Occurrence of MACEs, and Regulates Vascular Calcification via Targeting SULF1"],"prefix":"10.1111","volume":"133","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Intensive Care Unit General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Organ Transplant Center General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Organ Transplant Center General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Pathology Department General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5262-0029","authenticated-orcid":false,"given":"Boqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Organ Transplant Center General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.6817"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10658"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2021.1854091"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2020.01.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03208-z"},{"issue":"5","key":"e_1_2_7_7_1","first-page":"493","article-title":"End\u2010Stage Renal Disease: Medical Management","volume":"104","author":"Wouk N.","year":"2021","journal-title":"American Family Physician"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606180"},{"issue":"5","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1053\/j.ajkd.2016.05.021","article-title":"Intensive Hemodialysis and Treatment Complications and Tolerability","volume":"68","author":"Morfin J. 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