{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:09:14Z","timestamp":1772989754629,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013221","name":"Razi Vaccine and Serum Research Institute","doi-asserted-by":"publisher","award":["3\u201035\u20101851\u2010114\u2010961101"],"award-info":[{"award-number":["3\u201035\u20101851\u2010114\u2010961101"]}],"id":[{"id":"10.13039\/501100013221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes mellitus is linked to liver dysfunction and gut dysbiosis, and probiotics, especially\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    strains, are considered potential biotherapeutics for improving metabolic health. In this study, 15 lactic acid bacteria were isolated from traditional dairy products in Northwestern Iran and assessed for probiotic properties, including acid and bile tolerance, aggregation, hydrophobicity, antibacterial activity, and safety. Strain\n                    <jats:sc>ad<\/jats:sc>\n                    1 exhibited high acid (71.13%\u2009\u00b1\u20090.62% at pH\u20092.5, 3\u2009h) and bile tolerance (74.31%\u2009\u00b1\u20090.65% at 0.3% oxgall, 4\u2009h), strong autoaggregation (69.61%), and broad antibacterial activity, notably against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (21.4\u2009mm inhibition zone). Additionally, it was non\u2010hemolytic and sensitive to all eight tested antibiotics. To evaluate its antidiabetic potential,\n                    <jats:sc>ad<\/jats:sc>\n                    1 was administered to streptozotocin\u2010induced diabetic rats for 4\u2009weeks. Results showed significant reductions in ALT (60.6\u2009\u00b1\u20091.3 to 45.5\u2009\u00b1\u20090.8\u2009U\/L), AST (93.5\u2009\u00b1\u20091.0 to 60.1\u2009\u00b1\u20091.2\u2009U\/L), ALP (264.1\u2009\u00b1\u200934.2 to 191.3\u2009\u00b1\u200928.2\u2009U\/L), and blood glucose (311.9\u2009\u00b1\u200937.2 to 153.1\u2009\u00b1\u200936.9\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Histopathological analysis confirmed reduced hepatic damage and steatosis. In conclusion,\n                    <jats:italic>Lacticaseibacillus casei<\/jats:italic>\n                    strain\n                    <jats:sc>ad<\/jats:sc>\n                    1 shows strong probiotic potential, along with hepatoprotective and antihyperglycemic effects, making it a promising candidate for T2DM management.\n                  <\/jats:p>","DOI":"10.1111\/apm.70112","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T11:19:12Z","timestamp":1764760752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Probiotic Potential of\n                    <i>Lacticaseibacillus casei<\/i>\n                    Isolated From Traditional Dairy Products and Its Hepatoprotective Effects in\n                    <scp>STZ<\/scp>\n                    \u2010Induced Diabetic Rats"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-2920","authenticated-orcid":false,"given":"Yousef","family":"Nami","sequence":"first","affiliation":[{"name":"Department of Food Biotechnology, Branch for Northwest &amp; West Region, Agricultural Biotechnology Research, Institute of Iran Agricultural Research, Education and Extension Organization (AREEO)  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parsa","family":"Johari","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Tabriz Higher Education Institute of Rab\u2010Rashid  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-3032","authenticated-orcid":false,"given":"Alireza","family":"Dehnad","sequence":"additional","affiliation":[{"name":"Department of Livestock Bacterial Diseases Research, Razi Vaccine and Serum Research Institute Agricultural Research, Education and Extension Organization (AREEO)  Karaj 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