{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:00:37Z","timestamp":1787842837288,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prostate cancer is the most common malignancy among men worldwide, and treatment response depends on tumor radiosensitivity. Micrornas (mirnas) are key regulators of cell proliferation, apoptosis, and dna damage response, and have been implicated in therapy resistance. However, their roles in prostate cancer radioresponse remain incompletely understood. This study investigated the expression patterns of ten selected mirnas associated with radiation resistance in other cancers in prostate cancer models. Radiation\u2010resistant pc\u20103, radiation\u2010sensitive lncap, and normal prostate epithelial (hprec) cells were exposed to 0, 2, 4, 6, and 8 gy of ionizing radiation. Mirna expression levels were analyzed by quantitative pcr using snord48 as an internal control and calculated with the 2\u2009\u2212\u2009\u03b4\u03b4ct method. In pc\u20103 cells, mir\u201020a\u20105p, mir\u2010128\u20103p, and mir\u2010135b\u20105p showed significant dose\u2010dependent upregulation, whereas mir\u201023b\u20103p and mir\u2010381\u20103p were downregulated. Mir\u2010128\u20103p correlated positively with radiation dose, while mir\u201023b\u20103p and mir\u2010381\u20103p showed negative correlations. Lncap cells exhibited moderate, non\u2013dose\u2010dependent mirna changes. Distinct mirna signatures differentiate radiation\u2010resistant and radiation\u2010sensitive prostate cancer cells. Mir\u201020a\u20105p, mir\u2010128\u20103p, and mir\u2010135b\u20105p may contribute to radioresistance, whereas mir\u201023b\u20103p and mir\u2010381\u20103p may act as radiosensitizers.<\/jats:p>","DOI":"10.1111\/apm.70141","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:13:23Z","timestamp":1768385603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative\n                    <scp>miRNA<\/scp>\n                    Expression Profiling Reveals Candidates Involved in Prostate Cancer Radioresistance"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-9848","authenticated-orcid":false,"given":"Sercan","family":"Ergun","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Ondokuz Mayis University  Samsun 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