{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:22:40Z","timestamp":1774491760845,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Goblet cell adenocarcinoma (GCA) is a rare tumor described exclusively in the appendix, comprising &lt;\u20091% of gastrointestinal tumors. The 2019 WHO classification of tumors of the digestive system has renamed and defined it. This study aims to analyze the clinical presentation and evaluate the histomorphological profile of GCA. A retrospective search of our database was done spanning a period of 10.5\u2009years (July 2014\u2013January 2025). Clinicopathological features were analyzed. Fourteen patients included had a median age of 50\u2009years at the time of diagnosis with a male to female ratio of 1:0.75. Six patients presented with symptoms of acute to subacute intestinal obstruction. On imaging, these patients revealed circumferential thickening in the ileocecal region. Three of the female patients presented with symptoms predominantly pertaining to the gynecological tract. Histopathological evaluation revealed tubules and clusters of goblet\u2010like mucinous cells with a variable number of endocrine cells and Paneth\u2010like cells. Overall mean survival was 26\u2009months and the median survival was 24\u2009months. Recognition of GCA warrants a high degree of suspicion as they may present to different clinical departments owing to highly variable presentation and can be mistaken for signet ring cell adenocarcinoma on biopsy samples.<\/jats:p>","DOI":"10.1111\/apm.70180","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:45:14Z","timestamp":1774485914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Goblet Cell Adenocarcinoma of Appendix\u2010 Clinicopathological Analysis of a Rare Neoplasm\u2014A Tertiary Care Center Study"],"prefix":"10.1111","volume":"134","author":[{"given":"Shilpi","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9907-7531","authenticated-orcid":false,"given":"Rajni","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagir","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimlee","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surbhi","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Pathology Govind Ballabh Pant Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjunath","family":"Pol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Kataria","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-9709","authenticated-orcid":false,"given":"Vineet","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Surgical Disciplines All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasenjit","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja","family":"Sakhuja","sequence":"additional","affiliation":[{"name":"Department of Pathology Govind Ballabh Pant Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.915028","article-title":"Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry","volume":"12","author":"Palmer K.","year":"2022","journal-title":"Frontiers in Oncology"},{"issue":"4","key":"e_1_2_15_3_1","first-page":"393","article-title":"Tumors of the Appendix Associating Histologic Features of Carcinoid and Adenocarcinoma","volume":"14","author":"Gagne F.","year":"1969","journal-title":"Annales D'anatomie Pathologique (Paris)"},{"issue":"3","key":"e_1_2_15_4_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00000478-198104000-00001","article-title":"Crypt Cell Carcinoma of the Appendix (So\u2010Called Adenocarcinoid Tumor)","volume":"5","author":"Isaacson P.","year":"1981","journal-title":"American Journal of Surgical Pathology"},{"issue":"6","key":"e_1_2_15_5_1","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1002\/1097-0142(197812)42:6<2781::AID-CNCR2820420638>3.0.CO;2-B","article-title":"Adenocarcinoid, a Mucin\u2010Producing Carcinoid Tumor of the Appendix: A Study of 39 Cases","volume":"42","author":"Warkel R. L.","year":"1978","journal-title":"Cancer"},{"issue":"10","key":"e_1_2_15_6_1","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/PAS.0b013e31817f1816","article-title":"Pathologic Classification and Clinical Behavior of the Spectrum of Goblet Cell Carcinoid Tumors of the Appendix","volume":"32","author":"Tang L. H.","year":"2008","journal-title":"American Journal of Surgical Pathology"},{"issue":"2","key":"e_1_2_15_7_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO Classification of Tumours of the Digestive System","volume":"76","author":"Nagtegaal I. D.","year":"2020","journal-title":"Histopathology"},{"issue":"7","key":"e_1_2_15_8_1","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/PAS.0000000000001056","article-title":"Histologic and Outcome Study Supports Reclassifying Appendiceal Goblet Cell Carcinoids as Goblet Cell Adenocarcinomas, and Grading and Staging Similarly to Colonic Adenocarcinomas","volume":"42","author":"Yozu M.","year":"2018","journal-title":"American Journal of Surgical Pathology"},{"issue":"6","key":"e_1_2_15_9_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/s41379-018-0003-0","article-title":"Mutational Landscape of Goblet Cell Carcinoids and Adenocarcinoma ex Goblet Cell Carcinoids of the Appendix Is Distinct From Typical Carcinoids and Colorectal Adenocarcinomas","volume":"31","author":"Johncilla M.","year":"2018","journal-title":"Modern Pathology"},{"key":"e_1_2_15_10_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00302","article-title":"Genomic Landscape of Appendiceal Neoplasms","volume":"2","author":"Ang C. S.","year":"2018","journal-title":"JCO Precision Oncology"},{"issue":"11","key":"e_1_2_15_11_1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00384-019-03387-y","article-title":"Epidemiology of and Prognostic Factors for Appendiceal Carcinomas: A Retrospective, Population\u2010Based Study","volume":"34","author":"Mo S.","year":"2019","journal-title":"International Journal of Colorectal Disease"},{"issue":"10","key":"e_1_2_15_12_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/modpathol.2016.105","article-title":"Adenocarcinoma Ex\u2010Goblet Cell Carcinoid (Appendiceal\u2010Type Crypt Cell Adenocarcinoma) is a Morphologically Distinct Entity With Highly Aggressive Behavior and Frequent Association With Peritoneal\/Intra\u2010Abdominal Dissemination: An Analysis of 77 Cases","volume":"29","author":"Reid M. D.","year":"2016","journal-title":"Modern Pathology"},{"issue":"10","key":"e_1_2_15_13_1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1097\/PAS.0b013e31804f7aa1","article-title":"Ovarian Metastases of Appendiceal Tumors With Goblet Cell Carcinoidlike and Signet Ring Cell Patterns: A Report of 30 Cases","volume":"31","author":"Hristov A. C.","year":"2007","journal-title":"American Journal of Surgical Pathology"},{"issue":"3","key":"e_1_2_15_14_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.14735\/amko2016220","article-title":"Carcinoid of the Appendix Goblet Cells Metastasize to the Orbit \u2010 a Clinical Case Report and Review of the Literature","volume":"29","author":"Matejka V. M.","year":"2016","journal-title":"Klinick\u00e1 Onkologie"},{"issue":"1","key":"e_1_2_15_15_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-018-1789-6","article-title":"Goblet Cell Carcinoid of the Appendix \u2010 Diagnostic Challenges and Treatment Updates: A Case Report and Review of the Literature","volume":"12","author":"Gilmore G.","year":"2018","journal-title":"Journal of Medical Case Reports"},{"issue":"6","key":"e_1_2_15_16_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.5858\/arpa.2013-0047-OA","article-title":"Goblet Cell Carcinoid Tumor, Mixed Goblet Cell Carcinoid\u2010Adenocarcinoma, and Adenocarcinoma of the Appendix: Comparison of Clinicopathologic Features and Prognosis","volume":"139","author":"Taggart M. W.","year":"2015","journal-title":"Archives of Pathology & Laboratory Medicine"},{"issue":"10","key":"e_1_2_15_17_1","first-page":"1013","article-title":"Goblet Cell Adenocarcinoma in the Digestive System: A Clinicopathological Analysis of 22 Cases","volume":"51","author":"Cao Z.","year":"2022","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"1","key":"e_1_2_15_18_1","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.6822","article-title":"Goblet Cell Adenocarcinoma of the Ascending Colon: An Underrecognized Diagnostic Pitfall","volume":"11","author":"Limaiem F.","year":"2023","journal-title":"Clinical Case Reports"},{"issue":"16","key":"e_1_2_15_19_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000033598","article-title":"Goblet Cell Adenocarcinoma of the Anal Canal With Perianal Paget Disease: A Rare Case Report With Literature Review","volume":"102","author":"Li M.","year":"2023","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"e_1_2_15_20_1","first-page":"45","article-title":"Goblet\u2010Cell Carcinoid of the Colon","volume":"70","author":"Paklina O. 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C.","year":"2019","journal-title":"Journal of Surgical Oncology"},{"issue":"11","key":"e_1_2_15_31_1","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/cncr.32881","article-title":"The Chicago Consensus on Peritoneal Surface Malignancies: Management of Appendiceal Neoplasms","volume":"126","author":"Chicago Consensus Working G","year":"2020","journal-title":"Cancer"},{"key":"e_1_2_15_32_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.suronc.2020.12.003","article-title":"Is Adjuvant Chemotherapy Beneficial for Stage II\u2010III Goblet Cell Carcinoid\/Goblet Cell Adenocarcinoma of the Appendix?","volume":"36","author":"Zakka K.","year":"2021","journal-title":"Surgical Oncology"},{"key":"e_1_2_15_33_1","article-title":"The Optimal Approach to Surgical Management of Goblet Cell Carcinoid of the Appendix: A Systematic Review","volume":"14","author":"Salama M. M.","year":"2024","journal-title":"Diagnostics (Basel, Switzerland)"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.70180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apm.70180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.70180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:46:29Z","timestamp":1774489589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.70180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/apm.70180"],"URL":"https:\/\/doi.org\/10.1111\/apm.70180","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70180"}}