{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:00:19Z","timestamp":1780707619524,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>It remains a challenge to obtain well\u2010preserved tissue samples from deceased patients\u00a0as access to regular autopsy is limited. Minimally invasive autopsy (MIA) is a potential alternative to the complete diagnostic autopsy because of its efficacy in providing non\u2010autolyzed tissue samples and its increased acceptability amongst the bereaved. The study follows an exploratory, prospective design without any kind of intervention. Inclusion criteria are deceased adults (\u2265\u200918\u2009years), confirmed signs of death, uncertain or multifactorial cause of death, present or previous infection, and permission from next of kin to perform MIA, defined by ultrasound (US)\u2010guided samples from the heart, lungs, liver, spleen, and kidneys using a TruCut semi\u2010automatic coaxial needle (14G; 16\u2009cm length). Tissue samples, fixed in BiopSafe 20\u2009mL formalin test tubes, are sent for pathological evaluation. The primary outcome is the achievement of well\u2010preserved tissue samples, representative of the target organ and suitable for histopathological evaluation and diagnosis. An exploratory outcome is to establish the degree of clinico\u2010pathological discrepancies between pre\u2010mortem clinical status and post\u2010mortem pathological descriptions. This investigator\u2010initiated study is designed to validate the feasibility of MIA to enable fast\u2010track post\u2010mortem evaluation in an ICU environment.<\/jats:p>","DOI":"10.1111\/apm.70190","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:45:45Z","timestamp":1774917945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rationale and Design of the\n                    <scp>MIA<\/scp>\n                    Trial: A Proof\u2010of\u2010Concept Study of Minimally Invasive Autopsy in an Infectious Cause of Death in a Scandinavian\n                    <scp>ICU<\/scp>\n                    Setting"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1489-8915","authenticated-orcid":false,"given":"Fridtjof Gjerdrum","family":"Helgesen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Zealand University Hospital  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