{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:41:36Z","timestamp":1788381696500,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The conceptual transition from the \u201cRed Complex\u201d paradigm to the \u201cEcological Plaque Hypothesis\u201d has fundamentally reshaped the understanding of periodontitis, but a quantitative mapping of this intellectual evolution and its emerging research frontiers remains limited. This study systematically characterized the global research landscape and evolutionary trends of the oral microbiome in periodontitis from 2000 to 2025. English\u2010language articles published between 2000 and 17 November 2025 were retrieved from the Web of Science Core Collection and Scopus databases. After deduplication, bibliometric analyses were performed on 2827 unique publications to evaluate spatiotemporal distributions, collaboration patterns, thematic evolution, and citation bursts. The results revealed exponential growth in publications, particularly after 2020, with the United States and China leading global contributions. Thematic evolution analyses demonstrated a clear shift from single\u2010pathogen\u2013focused research, exemplified by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    , toward ecological frameworks emphasizing dysbiosis and microbial community structure. Recent citation bursts highlighted growing attention to broader microbial taxa, inflammatory mediators, clinically relevant periodontal indicators, microbiome\u2010based therapeutic strategies, and methodological standardization. Overall, research on the oral microbiome in periodontitis has evolved toward a host\u2013microbiome systems biology framework, with future studies likely to emphasize functional multi\u2010omics integration, AI\u2010assisted diagnostics, and precision interventions targeting oral\u2013systemic health links.\n                  <\/jats:p>","DOI":"10.1111\/apm.70209","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:56:23Z","timestamp":1776689783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mapping the Research Landscape and Evolutionary Trends of the Oral Microbiome in Periodontitis"],"prefix":"10.1111","volume":"134","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology General Hospital of the Central Theater Command  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Stomatology General Hospital of the Central Theater Command  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology General Hospital of the Central Theater Command  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-2156","authenticated-orcid":false,"given":"Qingshan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Stomatology General Hospital of the Central Theater Command  Wuhan 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