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These biofilms are influenced by regulatory circuits, transcription factors, and morphogenetic changes that promote biofilm development and drug resistance. The biofilm matrix, including \u03b2\u2010glucans and extracellular DNA, hinders antifungal penetration. Next\u2010generation approaches to controlling\n                    <jats:italic>Candida<\/jats:italic>\n                    biofilms include small\u2010molecule inhibitors, quorum\u2010sensing inhibitors, enzyme\u2010based ECM inhibitors, and nanoparticle\u2010mediated drug delivery platforms. Marine\u2010derived metabolites, antimicrobial peptides, and monoclonal antibodies are also discussed for their antibiofilm activity. Innovative in\u00a0vitro and in\u00a0vivo models are presented for assessing biofilm behavior and treatment response. Polymicrobial biofilms, including\n                    <jats:italic>Candida<\/jats:italic>\n                    and bacteria, are also discussed. Obstacles to controlling\n                    <jats:italic>Candida<\/jats:italic>\n                    biofilms include antifungal resistance, therapeutic agent toxicity, and regulatory hurdles. Future directions include CRISPR\u2010based gene editing, antifungal vaccines, and omics\u2010based target identification. This review emphasizes the importance of multidisciplinary, biofilm\u2010centric therapeutic strategies in reducing the global health impact of\n                    <jats:italic>Candida<\/jats:italic>\n                    biofilm\u2010related infections and advancing innovative antifungal therapies.\n                  <\/jats:p>","DOI":"10.1111\/apm.70214","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:45:38Z","timestamp":1777365938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Breaking the Barrier: Cutting\u2010Edge Microbial Strategies Against\n                    <i>Candida<\/i>\n                    Biofilm Infections"],"prefix":"10.1111","volume":"134","author":[{"given":"Utkalika","family":"Mallick","sequence":"first","affiliation":[{"name":"Centre for Biotechnology Siksha \u2018O\u2019 Anusandhan (Deemed To Be University)  Bhubaneswar Odisha 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