{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:05:46Z","timestamp":1779768346213,"version":"3.53.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Two crypt phenotypes (ACP): crypt rings in tandem (CRT) and crypts with lateral budding's (CLB's) were recently found interpolated amidst generally accepted crypt phenotypes (GACP, i.e., tubular, tubulovillous, villous and serrated). The frequency of cases with UC\u2010PDG, with CRT and with CLB's in GACP and in UC\u2010associated sporadic adenomas (UC\u2010aspa) was recorded. The possibility that the presence of ACP could increase histological discrimination between UC\u2010PDG and UC\u2010aspa was also explored. Two hundred digitalized biopsy\u2010cases were investigated: 100 with UC\u2010PDG and 100 with UC\u2010aspa. Six GACP and two types of cellular dysplasia: low\u2010grade (LGD) and high\u2010grade dysplasia (HGD) were found. CRT and CLB's were present in 66% of the 200 cases. A significantly higher number of cases with villous phenotype wihout or with HGD, with CLB's phenotype without or with HGD, and with tubulovillous phenotype with HGD were found in UC\u2010PDG than in UC\u2010asta. Several authors found no significant difference in the histological characteristics between UC\u2010protruding dysplastic lesions and US\u2010aspa. This work reveals, however, that the different number of cases with the above\u2010mentioned histological parameters present in each group permitted to discriminate between UC\u2010PDG and UC\u2010asta.<\/jats:p>","DOI":"10.1111\/apm.70216","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:17:11Z","timestamp":1778037431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Additional Crypt Phenotypes Lined With High\u2010Grade Cellular Dysplasia in Protruding Growths in Ulcerative Colitis"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-5729","authenticated-orcid":false,"given":"Carlos A.","family":"Rubio","sequence":"first","affiliation":[{"name":"Department of Oncology and Pathology Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Firmbach","sequence":"additional","affiliation":[{"name":"Institute of Pathology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Matek","sequence":"additional","affiliation":[{"name":"Institute of Pathology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[{"name":"Institute of Pathology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Lang\u2010Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Pathology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)31501-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-192508010-00006"},{"key":"e_1_2_9_4_1","first-page":"657","article-title":"Sommers SC Pathogenesis of Ulcerative Colitis","volume":"25","author":"Warren S.","year":"1949","journal-title":"American Journal of Pathology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195303)6:2<224::AID-CNCR2820060203>3.0.CO;2-H"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.8.5.423"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527209180974"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(75)80225-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.7.800"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80175-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/983459"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.031"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820360944"},{"key":"e_1_2_9_14_1","first-page":"4761","article-title":"Villous and Serrated Adenomatous Growth Bordering Carcinomas in Inflammatory Bowel Disease","volume":"20","author":"Rubio C. 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