{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:05:42Z","timestamp":1779768342863,"version":"3.53.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Holobiont describes all types of relationships between hosts and their associated microbial communities, which can also attenuate the virulence of pathogens by the host microbiome. The cross\u2010kingdom interactions between HIV,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and the human immune system have presented intriguing biological aspects. The human immunodeficiency 1 (HIV\u20101) virus is responsible for causing the acquired immune deficiency syndrome (AIDS) by infecting CD4\n                    <jats:sup>+<\/jats:sup>\n                    cells. HIV\u20101 internalization also depends on binding to coreceptors in the cell membrane, such as CCR5 and CXCR4. The expression of these chemokine receptors, as well as their ligands, can be modulated by the presence of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    PAMPs. Thus, this review discusses the inflammatory response mechanism activated by the commensal fungi\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    that can modify the rate of immune cell infection by HIV\u20101. Despite the possibility of this crosstalk modulation, future research must validate the clinical significance of this holobiont interaction.\n                  <\/jats:p>","DOI":"10.1111\/apm.70224","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:14:49Z","timestamp":1778663689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Candida albicans<\/i>\n                    ,\n                    <scp>HIV<\/scp>\n                    And Immune System in a Holobiont Perspective"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4544-9701","authenticated-orcid":false,"given":"Lu\u00eds Henrique Nunes","family":"de Souza","sequence":"first","affiliation":[{"name":"Laboratory of Inflammation and Immunology Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3977-3364","authenticated-orcid":false,"given":"Guilherme Ferreira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation and Immunology Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-7288","authenticated-orcid":false,"given":"M\u00e1rcia Cibele Andrade","family":"dos Santos Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation and Immunology Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-0665","authenticated-orcid":false,"given":"Priscila Luiza","family":"Mello","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation and Immunology Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4882-5402","authenticated-orcid":false,"given":"Luiz Eduardo Nunes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation and Immunology Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq057"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004093"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.02.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105870"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0619-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12977"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.07.009"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27284-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001768"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00470-21"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283536ba8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399284"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27956"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072814"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181776bc7"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3897"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.04.011"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2024.102507"},{"issue":"4","key":"e_1_2_12_20_1","article-title":"The Role of IL\u201017 in Protection Against Mucosal Candida Infections","volume":"3","author":"Mengesha B. 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