{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:11:39Z","timestamp":1792606299061,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    High\u2010risk human papillomavirus (HPV) infection is the main cause of cervical cancer and a central target of vaccination and screening programs. This study aimed to evaluate temporal changes in high\u2010risk HPV prevalence and genotype distribution and their association with cytological and histological findings in an opportunistic screening population. Cervical cytology samples processed in 2013\u20132015 and 2022\u20132024 at a tertiary center in Spain were analyzed using the same high\u2010risk HPV assay (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094724). Age\u2010standardized prevalence and multivariable logistic regression models were applied, and birth cohort (\u2265\u20091994 vs. &lt;\u20091994) was used as an ecological proxy for vaccination exposure. After age standardization, high\u2010risk HPV prevalence declined from 35.2% in 2013\u20132015 to 22.8% in 2022\u20132024, and screening in the later period was independently associated with lower odds of HPV infection (adjusted odds ratio 0.53). Most high\u2010risk genotypes decreased over time, whereas HPV45 and HPV68 showed higher adjusted odds of detection. Coinfection prevalence declined. HPV positivity increased with cytological severity, and high\u2010grade lesions clustered mainly around HPV16, HPV31, HPV52, HPV58 and HPV66. These findings highlight evolving patterns of high\u2010risk HPV genotype distribution and support genotype\u2010specific surveillance.\n                  <\/jats:p>","DOI":"10.1111\/apm.70234","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:31:47Z","timestamp":1783492307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010Risk Human Papillomavirus Prevalence and Genotype Distribution in Two Opportunistic Cervical Screening Periods in Spain: A Tertiary Hospital\u2010Based Study"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-4967","authenticated-orcid":false,"given":"Cristina","family":"D\u00edaz del Arco","sequence":"first","affiliation":[{"name":"Department of Legal Medicine, Psychiatry and Pathology, School of Medicine Complutense University of Madrid  Madrid Spain"},{"name":"Department of Pathology, Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Aguilera Herv\u00e1s","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Ram\u00edrez Mena","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Garc\u00eda Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Garc\u00eda L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ortega Medina","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Psychiatry and Pathology, School of Medicine Complutense University of Madrid  Madrid Spain"},{"name":"Department of Pathology, Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-3553","authenticated-orcid":false,"given":"Mar\u00eda Jes\u00fas","family":"Fern\u00e1ndez Ace\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of 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