{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:59:42Z","timestamp":1790319582841,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This retrospective study explored the relationship of serum neutrophil\u2010to\u2010lymphocyte ratio (NLR) and fibrinogen\u2010to\u2010albumin ratio (FAR) with disease activity and lupus nephritis (LN) in systemic lupus erythematosus (SLE) and assessed the clinical value of the derived combination model. Patients (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009147) with SLE were enrolled in the final analysis. Peripheral blood NLR and FAR also differed between subgroups based on LN absence\/presence: LN (79 cases) and non\u2010LN groups (68 cases) were independently associated with SLE disease activity and LN onset according to univariate and multivariate logistic regression results. Crucially, the NLR and FAR composite model demonstrated potentially auxiliary performance superior to the conventional indicator composite model (anti\u2010dsDNA, complement C3\/C4, 24\u2010h UPr), yielding an area under the ROC curve (AUC) of 0.865 for severe disease activity (95% CI: 0.799\u20130.915, sensitivity: 0.833, specificity: 0.769) and 0.922 for LN development (95% CI: 0.867\u20130.962, sensitivity: 0.785, specificity: 0.941). In conclusion, peripheral blood NLR and FAR may serve as potentially useful auxiliary biomarkers for identifying severe disease activity and LN in patients with SLE. These exploratory findings were obtained from a single\u2010center, small\u2010scale population. Therefore, multi\u2010center prospective cohort studies with large\u2010scale populations are needed to confirm their clinical applicability and generalizability.\n                  <\/jats:p>","DOI":"10.1111\/apm.70247","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:50:06Z","timestamp":1788220206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral Blood Neutrophil\u2010to\u2010Lymphocyte Ratio Combined With Fibrinogen\u2010to\u2010Albumin Ratio Assists in Identifying Systemic Lupus Erythematosus Activity and Lupus Nephritis"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8472-0732","authenticated-orcid":false,"given":"Shengnan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218272"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102374"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC202006020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2478\/rir-2022-0006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102871"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0141-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1763793"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171310"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30237-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070928"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-15165-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2025-001795"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2016.1154788"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-016-2335-5"},{"key":"e_1_2_10_16_1","first-page":"11026","article-title":"Neutrophil\u2010Lymphocyte Ratio in Systemic Lupus Erythematosus Disease: A Retrospective Study","volume":"8","author":"Li L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-1995"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22633"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1450"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05797-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9833509"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24621"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.365"},{"key":"e_1_2_10_25_1","first-page":"288","article-title":"Systemic Lupus Erythematosus Disease Activity Index 2000","volume":"29","author":"Gladman D. 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