{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:18:01Z","timestamp":1787725081311,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aortic dissection (AD) is a fatal cardiovascular emergency. This study explored the clinical value and mechanism of the LINC00152\/miR\u2010145\u20105p\/KLF4 ceRNA axis in AD. 105\u2009\n                    <jats:sc>ad<\/jats:sc>\n                    patients and 55 healthy controls were enrolled. LINC00152, miR\u2010145\u20105p, and KLF4 levels were measured by qRT\u2010PCR. ROC and Cox regression analyses assessed diagnostic and prognostic value. Dual\u2010luciferase reporter and rescue experiments in Ang II\u2010induced HASMCs validated the ceRNA axis. As a result, LINC00152 and KLF4 were upregulated, while miR\u2010145\u20105p was downregulated in AD patients. The three molecules showed good diagnostic efficacy (combined AUC\u2009=\u20090.9087). LINC00152, KLF4, and their joint risk signature were independent prognostic factors for adverse outcomes. Mechanistically, LINC00152 sponged miR\u2010145\u20105p to upregulate KLF4, promoting pro\u2010inflammatory factors (TNF\u2010\u03b1, IL\u20101\u03b2) and matrix metalloproteinases (MMP\u20102, MMP\u20109) in HASMCs. In conclusion, the LINC00152\/miR\u2010145\u20105p\/KLF4 ceRNA axis shows preliminary diagnostic and prognostic potential for AD, and drives AD development by regulating vascular inflammation and extracellular matrix degradation, which may serve as a candidate molecular target for subsequent translational research.\n                  <\/jats:p>","DOI":"10.1111\/apm.70248","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:34:10Z","timestamp":1787538850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>LINC00152<\/scp>\n                    \/\n                    <scp>miR<\/scp>\n                    \u2010145\u20105p\/\n                    <scp>KLF4 ceRNA<\/scp>\n                    Axis: Diagnostic and Prognostic Value in Aortic Dissection"],"prefix":"10.1111","volume":"134","author":[{"given":"Xiaomei","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5835-5799","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091964"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.11.032"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.31083\/RCM44307"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"294","article-title":"Current Status and 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