{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:59:37Z","timestamp":1790319577734,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R306\u2010A18169"],"award-info":[{"award-number":["R306\u2010A18169"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Graft inflammation and fibrosis are associated with progressive fibrosis and potential graft loss after liver transplantation, but diagnosis relies on invasive biopsies. Torque teno virus (TTV) may be a noninvasive marker of functional immunity, however its association with these changes remains unclear. In this Nordic multicenter cohort study, plasma samples collected with biopsies were analyzed for TTV load, and biopsies were scored for inflammation and fibrosis. Associations and performance of TTV versus tacrolimus were evaluated using logistic regression and ROC curves. TTV was categorized using the Youden Index. Among 287 liver transplant recipients, median age was 55, mean TTV load 5 log\n                    <jats:sub>10<\/jats:sub>\n                    copies\/mL and median time from transplantation to TTV measurement 12\u2009months. Low TTV load was associated with higher odds of fibrosis (aOR 2.96 [95% CI 1.40\u20136.25], adjusted for time since transplantation). Compared with tacrolimus, TTV load remained associated with fibrosis (2.64 [1.19\u20135.85]), whereas tacrolimus did not (1.16 [0.95\u20131.42]). The model including both markers had the highest AUC (0.69 [0.60\u20130.78]). At the optimal threshold, TTV demonstrated 64% sensitivity and specificity, positive predictive value 20% and negative predictive value 93%. TTV load was not significantly associated with inflammation. In conclusion, TTV load may support risk\u2010stratified biopsy strategies, requiring external validation.\n                  <\/jats:p>","DOI":"10.1111\/apm.70254","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:16:01Z","timestamp":1788336961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Torque Teno Virus Load Is Associated With Fibrosis in Protocol Biopsies Following Liver Transplantation: A Nordic Multicenter Cohort Study"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1489-9207","authenticated-orcid":false,"given":"Delal","family":"Akdag","sequence":"first","affiliation":[{"name":"Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Hepatic Malignancy Surgical Research Unit (HEPSURU), Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Viro\u2010Immunology Research Unit, Department of Infectious Diseases Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanett","family":"Klubien","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Hepatic Malignancy Surgical Research Unit (HEPSURU), Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Viro\u2010Immunology Research Unit, Department of Infectious Diseases Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3359-7734","authenticated-orcid":false,"given":"Andreas Arendtsen","family":"Rostved","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Viro\u2010Immunology Research Unit, Department of Infectious Diseases Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9550-4767","authenticated-orcid":false,"given":"Allan","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Kirkby","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro Linno","family":"Willemoe","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Chiranth","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010G\u00f6ran","family":"Ericzon","sequence":"additional","affiliation":[{"name":"Department of Transplantation Surgery, CLINTEC, Karolinska Institute Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-8113","authenticated-orcid":false,"given":"Carl","family":"Jorns","sequence":"additional","affiliation":[{"name":"Department of Transplantation Surgery, CLINTEC, Karolinska Institute Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bennet","sequence":"additional","affiliation":[{"name":"Department of Surgery Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Nordin","sequence":"additional","affiliation":[{"name":"Transplantation and Liver Surgery Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"\u00c5berg","sequence":"additional","affiliation":[{"name":"Transplantation and Liver Surgery Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Georg","family":"Hillings\u00f8","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-7455","authenticated-orcid":false,"given":"Susanne Dam","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Viro\u2010Immunology Research Unit, Department of Infectious Diseases Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-1946","authenticated-orcid":false,"given":"Hans\u2010Christian","family":"Pommergaard","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Hepatic Malignancy Surgical Research Unit (HEPSURU), Department of Digestive Diseases, Transplantation and General Surgery Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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