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This study investigated GHS\u2010R1a regulation in periodontal tissues exposed to experimental periodontitis (EP), orthodontic tooth movement (OTM), or both. Human periodontal fibroblasts were stimulated with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , static tensile strain, or their combination, and GHS\u2010R1a expression was evaluated by RT\u2010qPCR. In\u00a0vivo experiments were conducted in rats subjected to EP, OTM, or combined treatment. Gingival GHS\u2010R1a expression was assessed by RT\u2010qPCR and immunohistochemistry, while alveolar bone loss was quantified histometrically. Combined bacterial and mechanical stimulation markedly increased GHS\u2010R1a expression in periodontal fibroblasts, whereas either stimulus alone produced minimal changes. Similarly, combined EP and OTM induced a pronounced early increase in gingival GHS\u2010R1a gene and protein expression, which declined over time. Animals exposed to both conditions also exhibited significantly greater alveolar bone loss. These findings demonstrate that periodontal inflammation and orthodontic loading dynamically regulate GHS\u2010R1a, with early upregulation followed by attenuation during prolonged inflammation. The ghrelin\/GHS\u2010R1a system may therefore contribute to the periodontal response to concurrent inflammatory and biomechanical stimuli and participate in maintaining tissue homeostasis under inflammatory stress.\n                  <\/jats:p>","DOI":"10.1111\/apm.70259","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:51:40Z","timestamp":1788483100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis and Mechanical Forces Modulate Ghrelin Receptor in Periodontal Tissues"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-5947","authenticated-orcid":false,"given":"Andressa Vilas Boas","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Periodontology and Operative Dentistry University Medical Center of the Johannes Gutenberg University  Mainz 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Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0458-3900","authenticated-orcid":false,"given":"Isis Jord\u00e3o Pinheiro","family":"Ribaldo","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, School of Dentistry at Araraquara S\u00e3o Paulo State University (UNESP)  Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0998-1717","authenticated-orcid":false,"given":"Marjan","family":"Nokhbehsaim","sequence":"additional","affiliation":[{"name":"Section of Experimental Dento\u2010Maxillo\u2010Facial Medicine University Hospital Bonn  Bonn 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