{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:30:37Z","timestamp":1790742637545,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Schizophrenia is associated with the activation of the immune\/inflammatory system. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), a positive acute phase protein, may be associated with schizophrenia and antipsychotic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The serum high\u2010sensitivity <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) levels of 36 schizophrenic patients undergoing clozapine, olanzapine or risperidone treatment and 36 sex\u2010matched healthy subjects were collected. The difference in hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels between the schizophrenic and the control groups was estimated using <jats:sc>ancova<\/jats:sc>. <jats:sc>anova<\/jats:sc> was performed to examine the differences in the hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels between three antipsychotic groups (clozapine, olanzapine and risperidone).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:sc>ancova<\/jats:sc> adjusted for age and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) revealed a significant increase in the hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels in the schizophrenic group (1.4\u2009mg\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2009=1.5\u2009mg\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) in comparison with the control group (0.9\u2009mg\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2009=\u20091.4\u2009mg\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u2009=\u20090.013). <jats:sc>anova<\/jats:sc> revealed no statistical difference of age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> in three antipsychotic groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.83, 0.90 and 0.71, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The elevation of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> level is seen in chronic schizophrenia under antipsychotic treatment; however, studies with a larger sample size are required to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12078","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T04:41:13Z","timestamp":1369111273000},"source":"Crossref","is-referenced-by-count":18,"title":["Increased high\u2010sensitivity <scp>C<\/scp>\u2010reactive protein levels in <scp>T<\/scp>aiwanese schizophrenic patients"],"prefix":"10.1111","volume":"5","author":[{"given":"Chin\u2010Chuen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yih","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiao\u2010Lai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.06.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(98)00140-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23512"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e328080ca44"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-10-199805150-00021"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.03.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.03.022"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.07.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.052605"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310393378"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.12.1971"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.10.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00757.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2002.01066.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.10.005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111044"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000213565"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32833643fd"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(97)00057-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(96)02915-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.06.005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111535"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.4.461"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.12.006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.22.2131"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00042-6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(96)00037-0"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603329"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01804-6"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300756"}],"container-title":["Asia-Pacific 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