{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:29:06Z","timestamp":1759530546738},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Serotonin transporter gene linked polymorphic region, also called 5<jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>, is a candidate in the genetics of bipolar disorder; however, the results of previous association studies are inconsistent. Several explanations have been proposed for that inconsistency; among them are the existing differences both in the genetic basis of bipolar disorder subtypes and the genetic backgrounds of the studied populations. We aimed to investigate the association of 5<jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content> with bipolar disorder type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (BP\u20101) in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ranian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2013control study, 146 patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u20101 and 165 controls were recruited. The patients were selected through the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tructured <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linical <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nterview for <jats:styled-content style=\"fixed-case\"><jats:italic>D<\/jats:italic><\/jats:styled-content><jats:italic>iagnostic and<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic><\/jats:styled-content><jats:italic>tatistical<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>anual of<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>ental<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>D<\/jats:italic><\/jats:styled-content><jats:italic>isorders, 4th edition<\/jats:italic>. It was required that the patients do not have any present history of general medical conditions, substance abuse, and concurrent major psychiatric disorders. The polymorphism was evaluated by blood sampling and subsequent <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> extraction, polymerase chain reaction, and agarose gel electrophoresis. Chi\u2010square test was used for analyzing allelic and genotype frequencies and two\u2010tailed <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> values were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> allele was significantly more frequent in the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u20101 patients compared with the controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.02, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> allele odds ratio\u2009=\u20091.5, confidence interval 95%\u2009=\u20091.06\u20132.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our statistically significant results suggest that the role of 5<jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content> in the pathogenesis of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u20101 needs to be clarified by further scrutiny in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ranian population and other populations of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ear <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ast.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12179","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T18:43:51Z","timestamp":1427222631000},"page":"92-97","source":"Crossref","is-referenced-by-count":3,"title":["Association involving serotonin transporter gene linked polymorphic region and bipolar disorder type 1 in <scp>I<\/scp>ranian population"],"prefix":"10.1111","volume":"8","author":[{"given":"Mohammad","family":"Ghadiri","sequence":"first","affiliation":[{"name":"Iran Psychiatric Hospital Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issa","family":"Nourmohammadi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Fasihi Ramandi","sequence":"additional","affiliation":[{"name":"Research Center of Molecular Biology Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsan","family":"Moazen Zadeh","sequence":"additional","affiliation":[{"name":"Mental Health Research Center Tehran Psychiatric Institute Iran University of Medical Sciences  Tehran 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