{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:19:08Z","timestamp":1791299948552,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371499"],"award-info":[{"award-number":["81371499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30971586"],"award-info":[{"award-number":["30971586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Our purpose is to investigate whether polymorphisms of 102 <jats:styled-content style=\"fixed-case\">T\/C<\/jats:styled-content> and \u20101438<jats:styled-content style=\"fixed-case\">A\/G<\/jats:styled-content> in <jats:italic>5<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>HTR<\/jats:italic><\/jats:styled-content><jats:italic>2<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content> are associated with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ourette syndrome (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>an population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 178 <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> trios were recruited in this study. After the allelic and genotypic distributions of two polymorphisms were genotyped using polymerase chain reaction and restriction fragment length polymorphism (PCR\u2010RFLP), we compared their genetic distributions with what is expected with <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ardy\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>einberg to explore whether there might be an association of these polymorphisms with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> by haplotype relative risk (<jats:styled-content style=\"fixed-case\">HRR<\/jats:styled-content>) and transmission disequilibrium test (<jats:styled-content style=\"fixed-case\">TDT<\/jats:styled-content>) statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that no significant associations were found between the <jats:styled-content style=\"fixed-case\">HTR2A<\/jats:styled-content> 102 <jats:styled-content style=\"fixed-case\">T\/C<\/jats:styled-content> and \u20101438<jats:styled-content style=\"fixed-case\">A\/G<\/jats:styled-content> polymorphisms and <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> (for <jats:styled-content style=\"fixed-case\">HTR2A<\/jats:styled-content> 102 <jats:styled-content style=\"fixed-case\">T\/C<\/jats:styled-content>: <jats:styled-content style=\"fixed-case\">TDT<\/jats:styled-content>\u2009=\u20092.041, df\u2009=\u20091, <jats:italic>P<\/jats:italic>\u2009=\u20090.175; <jats:styled-content style=\"fixed-case\">HRR<\/jats:styled-content>\u2009=\u20091.468, \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20091.905, <jats:italic>P<\/jats:italic>\u2009=\u20090.168, 95% confidence interval: 0.850\u20132.535; for <jats:styled-content style=\"fixed-case\">HTR2A<\/jats:styled-content>: \u20101438A\/G, <jats:styled-content style=\"fixed-case\">TDT<\/jats:styled-content>\u2009=\u20090.093, df\u2009=\u20091, <jats:italic>P<\/jats:italic>\u2009=\u20090.819; <jats:styled-content style=\"fixed-case\">HRR<\/jats:styled-content>\u2009=\u20090.965, \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.018, <jats:italic>P<\/jats:italic>\u2009=\u20090.894, 95% confidence interval: 0.574\u20131.624).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study suggested that the <jats:styled-content style=\"fixed-case\">HTR2A<\/jats:styled-content> 102<jats:styled-content style=\"fixed-case\">T\/C<\/jats:styled-content> and \u20101438<jats:styled-content style=\"fixed-case\">A\/G<\/jats:styled-content> polymorphisms may not be associated with susceptibility to <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>, and thus do not play a major role in the development of <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>an population. However, these results need to be confirmed in a larger sample collected from different populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12185","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T03:35:44Z","timestamp":1428636944000},"page":"87-91","source":"Crossref","is-referenced-by-count":4,"title":["Lack of genetic association of 5\u2010<scp>HTR<\/scp>2<scp>A<\/scp> 102 <scp>T\/C<\/scp> and \u20101438<scp>A\/G<\/scp> polymorphisms with <scp>T<\/scp>ourette syndrome in a family\u2010based association study in a <scp>C<\/scp>hinese <scp>H<\/scp>an population"],"prefix":"10.1111","volume":"8","author":[{"given":"Longqiang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Ma","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Centre The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nailun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Qingdao Women &amp; Children Medical Healthcare Center  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[{"name":"Graduate School Peking Union Medical College  Beijing China"},{"name":"National Research Institute for Family Planning  Beijing China"},{"name":"World Health Organization Collaborating Centre for Research in Human Reproduction  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Genetic Laboratory The Affiliated Hospital of Medical College Qingdao University  Qingdao China"},{"name":"Prenatal Diagnosis Center The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-007-1003-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00346.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.08.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(90)90048-V"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90903-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960216)67:1<103::AID-AJMG18>3.0.CO;2-S"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.2.735"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000251210.98749.83"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.npp.1380241","article-title":"Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, Tourette's syndrome, and healthy controls","volume":"12","author":"Leckman J.F.","year":"1995","journal-title":"Neuropsychopharmacol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.101"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30320"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.08.030"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.1.76"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002100"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.03.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.09.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.12.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301528"}],"container-title":["Asia-Pacific Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fappy.12185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/appy.12185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:21:29Z","timestamp":1695543689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/appy.12185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,9]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/appy.12185"],"URL":"https:\/\/doi.org\/10.1111\/appy.12185","archive":["Portico"],"relation":{},"ISSN":["1758-5864","1758-5872"],"issn-type":[{"value":"1758-5864","type":"print"},{"value":"1758-5872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,9]]}}}