{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:19:58Z","timestamp":1791299998630,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Clinical, neuroimaging and other studies provided evidence that the dysfunction of the serotonin neurotransmitter system were found in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ourette syndrome (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>). This study is to explore the association between the polymorphism of <jats:styled-content style=\"fixed-case\">C861G<\/jats:styled-content> (rs6296) in <jats:styled-content style=\"fixed-case\"><jats:italic>HTR1B<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred ninety\u2010nine <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> patients (260 <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> trios and 39 <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> patients) and 388 healthy controls were collected. The genotype of <jats:styled-content style=\"fixed-case\">HTR1B C861G<\/jats:styled-content> was detected using <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aqman probes. The case\u2010control study and family\u2010based study was used separately to study association between <jats:styled-content style=\"fixed-case\">HTR1B C861G<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In case\u2010control study, no statistically significant difference was found in the distribution of <jats:styled-content style=\"fixed-case\">HTR1B C861G<\/jats:styled-content> polymorphism between <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> patients and controls (for genotype: \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20093.408, <jats:italic>P\u2009=<\/jats:italic>\u20090.182; for allele: \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.395, <jats:italic>P\u2009=<\/jats:italic>\u20090.530, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20090.934, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.754\u20131.156). In family\u2010based study, we observed nonsignificant over\u2010transmission of the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>861 allele in <jats:styled-content style=\"fixed-case\"><jats:italic>HTR1B<\/jats:italic><\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> offspring using the transmission disequilibrium test (<jats:styled-content style=\"fixed-case\">TDT<\/jats:styled-content>), haplotype relative risk (<jats:styled-content style=\"fixed-case\">HRR<\/jats:styled-content>) and haplotype\u2010based <jats:styled-content style=\"fixed-case\">HRR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HHRR<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">TDT<\/jats:styled-content> \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.410, <jats:italic>P\u2009=<\/jats:italic>\u20090.560; <jats:styled-content style=\"fixed-case\">HRR<\/jats:styled-content>\u2009=\u20091.151, \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.421, <jats:italic>P\u2009=<\/jats:italic>\u20090.517, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.753\u20131.759; <jats:styled-content style=\"fixed-case\">HHRR<\/jats:styled-content>\u2009=\u20090.919, \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.467, <jats:italic>P\u2009=<\/jats:italic>\u20090.495, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.720\u20131.172).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study suggested that the polymorphism of <jats:styled-content style=\"fixed-case\">HTR1B C861G<\/jats:styled-content> is not a risk factor for <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese population. However, the result should be replicated in larger sample and different population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12196","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T01:24:48Z","timestamp":1435627488000},"source":"Crossref","is-referenced-by-count":3,"title":["Association between the polymorphism of <scp>C861G<\/scp> (rs6296) in the serotonin 1<scp>B<\/scp> receptor gene and <scp>T<\/scp>ourette syndrome in <scp>H<\/scp>an <scp>C<\/scp>hinese people"],"prefix":"10.1111","volume":"9","author":[{"given":"Mingji","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Child Health Care The Affiliated Hospital of Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Child Health Care The Affiliated Hospital of Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Qingdao Municipal Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nailun","family":"Su","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Qingdao Women and Children Medical Health Care Center  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Genetic Laboratory The Affiliated Hospital of Medical College Qingdao University  Qingdao 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