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However, investigations are lacking on the characteristics of physiological measurement among these at\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we followed acutely inpatients with schizophrenia disorder for cause of death through record linkage to the Death Certification System in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwan. Cases of patients who died because of circulatory morbidity (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u20139 401\u2013443) before turning 65 years old were used. Each schizophrenia case was then matched with two mentally healthy controls for the age and sex, and date of laboratory examination. Clinical data of all subjects were obtained by reviewing medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 81 patients with schizophrenia who died from circulatory diseases at mean ages of 48.0\u2009\u00b1\u200910.7 years were investigated. The mean age at the final acute psychiatric hospitalization was 43.0\u2009\u00b1\u200910.9 years. Multivariate analysis showed that elevated fasting serum glucose levels (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI]<\/jats:styled-content> for odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u2009=\u20091.00\u20131.03), blood leukocyte counts (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> for odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u2009=\u20091.07\u20131.55), and heart rates on electrocardiogram (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.04\u20131.10) in the final psychiatric hospitalization collectively provided the predictive validity for premature circulatory death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Systemic inflammatory activation and autonomic nervous system dysfunction along with dysregulation of glucose metabolism rather than lipids could be the physiological characteristics of schizophrenia patients at risk of premature circulatory mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12207","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T11:59:22Z","timestamp":1440763162000},"page":"199-205","source":"Crossref","is-referenced-by-count":5,"title":["Physiological characteristics of patients with schizophrenia prematurely dying from circulatory diseases"],"prefix":"10.1111","volume":"8","author":[{"given":"Pao\u2010Huan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Ying","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Psychiatry School of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chian\u2010Jue","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Taipei City Psychiatric Center Taipei City Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Hsuan","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Psychiatry School of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou\u2010Hung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiao\u2010Chicy","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Psychiatry Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0414"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acn.12014"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1878-3317(10)60028-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.04.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2010.09.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.07.034"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000091257.27563.32"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12050599"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032804"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.80.6.570"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.6.625"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082606"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.08.007"},{"key":"e_1_2_5_16_1","unstructured":"Health Promotion Administration Ministry of Health and Welfare Taiwan. 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