{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:31:52Z","timestamp":1784683912258,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although emerging evidence has suggested an association between the <jats:styled-content style=\"fixed-case\">Val66M<\/jats:styled-content>et (rs6265) polymorphisms in brain\u2010derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) gene and the panic disorder, the conclusion is inclusive given the mixed results. This meta\u2010analysis reviewed and analyzed the recent studies addressing the potential association between the <jats:styled-content style=\"fixed-case\">Val66M<\/jats:styled-content>et polymorphisms and panic disorder susceptibility. Related case\u2013control studies were retrieved by database searching and selected according to established inclusion criteria. Six articles were identified, which explored the association between the <jats:styled-content style=\"fixed-case\">BDNF Val66M<\/jats:styled-content>et polymorphism and panic disorder. Statistical analyses revealed no association for the allele contrast and the dominant model. However, the recessive model showed a significant association between the <jats:styled-content style=\"fixed-case\">BDNF Val66M<\/jats:styled-content>et polymorphism and panic disorder (odds ratio\u2009=\u20091.26, 95% confidence interval\u2009=\u20091.04\u20131.52, z\u2009=\u20092.39, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Despite of some limitations, this meta\u2010analysis suggests that the <jats:styled-content style=\"fixed-case\">Val66M<\/jats:styled-content>et polymorphism of <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> gene is a susceptibility factor for panic disorder.<\/jats:p>","DOI":"10.1111\/appy.12228","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T06:56:42Z","timestamp":1450681002000},"source":"Crossref","is-referenced-by-count":20,"title":["Is the <scp>V<\/scp>al66<scp>M<\/scp>et polymorphism of the brain\u2010derived neurotrophic factor gene associated with panic disorder? A meta\u2010analysis"],"prefix":"10.1111","volume":"9","author":[{"given":"Kaiyuan","family":"Chen","sequence":"first","affiliation":[{"name":"Mental Health Center Shantou University Medical College  Shantou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Mental Health Center Zhengzhou Ninth People's Hospital  Zhengzhou Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mental Health Center Shantou University Medical College  Shantou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Hong","sequence":"additional","affiliation":[{"name":"Mental Health Center Shantou University Medical College  Shantou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Mental Health Center Shantou University Medical College  Shantou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Base The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Huang","sequence":"additional","affiliation":[{"name":"Mental Health Center Shantou University Medical College  Shantou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120972"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.09.022"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707509"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0348-04.2004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.07.006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2012.10.1.44"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.7.1242"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0702"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2015.12.1.112"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.10.1568"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e32832a9bbd"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90326-M"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.11120359"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.01.020"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.11060135"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077362"},{"key":"e_1_2_5_23_1","first-page":"27","article-title":"Lack of association between brain\u2010derived neurotrophic factor gene Val66Met polymorphisms and panic disorder in Korean population","volume":"4","author":"Lim S.W.","year":"2007","journal-title":"Psychiatry Invest"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-12-07929.1995"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.46"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.211"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2012.12.009"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120685"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.15.10.0706"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000151839.12032.1A"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540260400014401"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.04.018"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.07.013"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30332"}],"container-title":["Asia-Pacific Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fappy.12228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fappy.12228","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/appy.12228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:10:16Z","timestamp":1696486216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/appy.12228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/appy.12228"],"URL":"https:\/\/doi.org\/10.1111\/appy.12228","archive":["Portico"],"relation":{},"ISSN":["1758-5864","1758-5872"],"issn-type":[{"value":"1758-5864","type":"print"},{"value":"1758-5872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]},"article-number":"e12228"}}