{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:17:11Z","timestamp":1754194631574,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We used the population\u2010based database to investigate the trends, correlates, and disease patterns of antipsychotic use among elderly people in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Health Research Institutes provided a database of 1,000,000 random subjects for health service studies. We analyzed a sample of subjects over the age of 65 years from 1997 to 2005. The trends in and factors associated with antipsychotic use were detected. We also examined the proportions of antipsychotics used for psychiatric and medical disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 1\u2010year prevalence of antipsychotic use in elderly persons increased from 9.8% in 1997 to 12.8% in 2005. The prevalence of first\u2010generation antipsychotic (<jats:styled-content style=\"fixed-case\">FGA<\/jats:styled-content>) use increased from 9.8% to 11.6%, and the prevalence of second\u2010generation antipsychotic (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) use increased greatly from 0.01% to 2.02%. Higher prevalence of both <jats:styled-content style=\"fixed-case\">FGAs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SGAs<\/jats:styled-content> were associated with age and higher Charlson Comorbidity Index scores. Psychiatric disorders were commonly found in <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> users (80.8%), whereas only 19.3% of the <jats:styled-content style=\"fixed-case\">FGA<\/jats:styled-content> users had psychiatric disorders. Among the major psychiatric disorders, greater proportions of antipsychotic use were for senile and presenile organic psychotic conditions, other organic psychotic conditions, and affective psychoses. <jats:styled-content style=\"fixed-case\">FGAs<\/jats:styled-content> were much more commonly prescribed for nonpsychiatric disorders, including diseases of symptoms, signs, and ill\u2010defined conditions, the digestive system, and the respiratory system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The prevalence of antipsychotic use, particularly the use of <jats:styled-content style=\"fixed-case\">SGAs<\/jats:styled-content>, increased greatly from 1997 to 2005 among elderly persons in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwan. <jats:styled-content style=\"fixed-case\">SGAs<\/jats:styled-content> were most used by subjects with psychiatric disorders, and <jats:styled-content style=\"fixed-case\">FGAs<\/jats:styled-content> were most used by those with nonpsychiatric disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12230","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T02:39:07Z","timestamp":1450147147000},"page":"278-286","source":"Crossref","is-referenced-by-count":5,"title":["Trends, correlates, and disease patterns of antipsychotic use among elderly persons in <scp>T<\/scp>aiwan"],"prefix":"10.1111","volume":"8","author":[{"given":"Chia\u2010Lun","family":"Kuo","sequence":"first","affiliation":[{"name":"Tsaotun Psychiatric Center Ministry of Health and Welfare  Nantou Taiwan"},{"name":"Central Taiwan University of Science and Technology  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4242-6283","authenticated-orcid":false,"given":"I.\u2010Chia","family":"Chien","sequence":"additional","affiliation":[{"name":"Tsaotun Psychiatric Center Ministry of Health and Welfare  Nantou Taiwan"},{"name":"Department of Public Health &amp; 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