{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:50:10Z","timestamp":1759042210543,"version":"3.41.2"},"reference-count":4,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"General projects of medical and health of Zhejiang province","award":["2015127505"],"award-info":[{"award-number":["2015127505"]}]},{"name":"Public benefit technology application research planning project of Zhejiang province","award":["2012C33006"],"award-info":[{"award-number":["2012C33006"]}]},{"name":"Science and technology key planning project of Huzhou city","award":["2010GS07"],"award-info":[{"award-number":["2010GS07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>To investigate whether early improvement can predict 8\u2010week treatment outcome in generalized anxiety disorder (GAD) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>For 8\u00a0weeks, 226 GAD patients were randomly treated with escitalopram or venlafaxine. Early improvement was defined as a \u226720% reduction from baseline in Hamilton anxiety rating scale at week 1 or 2. The positive and negative predictive values were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>The positive and negative predictive values of early improvement in escitalopram or venlafaxine group at week 1 were (85.19%, 67.53%) vs (84.62%, 65.33%)<\/jats:p><\/jats:sec>Discussion<\/jats:title>The early improvement achieved within the first week treatment can predict a good 8\u2010week treatment outcome in GAD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12270","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T19:53:10Z","timestamp":1482177190000},"source":"Crossref","is-referenced-by-count":3,"title":["Early improvement predicts 8\u2010week treatment outcome in patients with generalized anxiety disorder treated with escitalopram or venlafaxine"],"prefix":"10.1111","volume":"9","author":[{"given":"Mincai","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospital Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxia","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospital Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospital Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiefeng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospital Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospital Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospital Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospital Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Affiliated ZhongDa Hospital Medical School of Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.07.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.02.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20214"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.07m03780"}],"container-title":["Asia-Pacific Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fappy.12270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fappy.12270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/appy.12270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:47:33Z","timestamp":1695473253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/appy.12270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/appy.12270"],"URL":"https:\/\/doi.org\/10.1111\/appy.12270","archive":["Portico"],"relation":{},"ISSN":["1758-5864","1758-5872"],"issn-type":[{"type":"print","value":"1758-5864"},{"type":"electronic","value":"1758-5872"}],"subject":[],"published":{"date-parts":[[2016,12,19]]},"article-number":"e12270"}}