{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:30:19Z","timestamp":1789979419686,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine (1) if the use of benzodiazepines and antidepressants during pregnancy may increase the risk of preterm birth and\/or low birth weight (LBW), and, if yes, (2) which types of benzodiazepines or antidepressants have stronger influences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was performed using a large claims database in Japan. Cases were mothers who had given birth to preterm and\/or LBW infants between 2005 and 2014 (737 with preterm births and 1615 with LBW). Controls were mothers who had neither experienced preterm birth nor given birth to an LBW infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 42\u00a0058 births were included. The maternal use of benzodiazepines was significantly associated with an increased risk of preterm birth (adjusted odds ratio [OR], 2.03; 95% confidence interval [CI], 1.11\u20103.69, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), while the maternal use of benzodiazepines was not significantly associated with LBW (adjusted OR, 1.55; 0.96\u20102.50). The use of antidepressants was not significantly associated with both preterm deliveries (adjusted OR, 0.57; 0.08\u20104.16) and LBW (adjusted OR, 0.56; 0.14\u20102.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Benzodiazepine use was associated with increased risk of preterm birth but not with LBW. Antidepressant use was not associated with both preterm deliveries and LBW.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12309","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:27:48Z","timestamp":1514982468000},"source":"Crossref","is-referenced-by-count":22,"title":["Maternal exposure to benzodiazepine and risk of preterm birth and low birth weight: A case\u2010control study using a claims database in Japan"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-5102","authenticated-orcid":false,"given":"Yusuke","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Health Promotion and Human Behavior Kyoto University Graduate School of Medicine\/School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Human Behavior Kyoto University Graduate School of Medicine\/School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshi A.","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Human Behavior Kyoto University Graduate School of Medicine\/School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.036"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.062554"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-005-0090-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp324"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.061"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000158118.75532.51"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.4.293"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03261.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.111"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Births: Preliminary data for 2012","volume":"62","author":"Hamilton B. 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