{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:16:19Z","timestamp":1792163779916,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002975","name":"Dainippon Sumitomo Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To evaluate efficacy and safety of lurasidone for the treatment of Asian patients with schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with schizophrenia from Japan, South Korea, Malaysia, and Taiwan were randomly assigned to 6\u00a0weeks of double\u2010blind treatment with 40 or 80\u00a0mg\/d of lurasidone or placebo. The primary efficacy measure was change from baseline to week 6 on the Positive and Negative Syndrome Scale (PANSS) total score. Efficacy was evaluated using a mixed\u2010model repeated\u2010measures (MMRM) analysis in the modified intention\u2010to\u2010treat (mITT) population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On the basis of the analysis for the mITT population, the estimated difference score for lurasidone 40 and 80\u00a0mg\/d vs placebo was \u22124.8 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.050) and \u22124.2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.080). For the full intention\u2010to\u2010treat (ITT) population, the difference score for lurasidone 40 and 80\u00a0mg\/d vs placebo was \u22125.8 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) and \u22124.2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). The most frequent adverse events in the lurasidone 40 and 80\u00a0mg\/d and placebo groups, respectively, were akathisia (7.3%, 10.4%, 3.3%), somnolence (6.0%, 2.6%, 0.7%), and vomiting (6.0%, 5.8%, 2.0%). The proportion of patients experiencing clinically significant weight gain (\u22657%) was 5.3% for lurasidone 40\u00a0mg\/d, 1.3% for 80\u00a0mg\/d, and 1.4% for placebo. End point changes in metabolic parameters and prolactin were comparable for both lurasidone groups and placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the ITT (but not the mITT) population, treatment with lurasidone was associated with significant improvement in the PANSS total score in patients with schizophrenia. Lurasidone was generally well tolerated with minimal impact on weight and metabolic parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12352","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T10:12:09Z","timestamp":1554459129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Lurasidone in the treatment of schizophrenia: Results of a double\u2010blind, placebo\u2010controlled trial in Asian patients"],"prefix":"10.1111","volume":"11","author":[{"given":"Teruhiko","family":"Higuchi","sequence":"first","affiliation":[{"name":"Japan Depression Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ishigooka","sequence":"additional","affiliation":[{"name":"Institute of CNS Pharmacology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaomi","family":"Iyo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National University Corporation Chiba University, Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Bin","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Gunaseli","family":"Ebenezer","sequence":"additional","affiliation":[{"name":"Hospital Raja Permaisuri Bainun UniKL Royal College of Medicine Perak  Ipoh Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei Yu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Wei\u2010Gong Memorial Hospital  Toufen City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yongin Mental Hospital  Yong\u2010in City South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Yeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Wonkwang University School of Medicine and Hospital  Iksan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-0389","authenticated-orcid":false,"given":"Shih Ku","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Taipei City Hospital SongDe Branch  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Naju National Hospital  Naju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Data Science Sumitomo Dainippon Pharma Co., Ltd.  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