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In this study, we examined the potential neural mechanisms through which MBCT may reduce anxiety in patients with mild\u2010to\u2010moderate GAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight weekly group MBCT sessions (2 h each) were conducted with 32 GAD patients. Resting\u2010state functional magnetic resonance imaging (fMRI) was used, along with clinical and mindfulness profiles. A regional homogeneity (ReHo) approach was applied, and resting\u2010state functional connectivity in the default mode network (DMN) using the posterior cingulate cortex (PCC) seed was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MBCT reduced the anxiety and increased the mindfulness abilities of patients. After MBCT, patients had reduced ReHo in broad regions of the limbic system, along with increased DMN functional connectivity in the anterior cingulate cortex (ACC) and bilateral insula. Overlapping regions of reduced ReHo and increased DMN functional connectivity were observed in the mid\u2010cingulate cortex (MCC) and bilateral insula. The increased PCC\u2010ACC and PCC\u2010insula functional connectivity following MBCT were related to anxiety improvements, suggesting a potential therapeutic mechanism for mindfulness\u2010based therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Group MBCT treatment appears to have effectively reduced anxiety symptoms in patients with mild\u2010to\u2010moderate GAD. Activation and functional connectivity appeared significantly different across some limbic regions after MBCT treatment. The salience network showed reduced ReHo and increased connectivity to the PCC. The DMN functional connectivity of the MCC may indicate reduced anxiety and improved mindfulness in GAD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12368","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T06:09:56Z","timestamp":1564380596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mindfulness\u2010based cognitive therapy is associated with distinct resting\u2010state neural patterns in patients with generalized anxiety disorder"],"prefix":"10.1111","volume":"11","author":[{"given":"Xing\u2010Rong","family":"Zhao","sequence":"first","affiliation":[{"name":"Mental Health Institute, the Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Department of Psychiatry The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang\u2010Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Faculty Kunming University of Science and Technology Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010Yuan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology East Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, The Second People's Hospital of Yunnan Province Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Yun","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ping","family":"Cao","sequence":"additional","affiliation":[{"name":"Mental Health Institute, the Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-2039","authenticated-orcid":false,"given":"Ya\u2010Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mental Health Institute, the Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2957-12.2012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005973"},{"key":"e_1_2_9_4_1","unstructured":"American Psychiatric Association. 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