{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:18:46Z","timestamp":1783041526514,"version":"3.54.6"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We explored the clinical efficacy and safety of modified electroconvulsive therapy (ECT) in the treatment of elderly patients with refractory depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 43 older patients with refractory depression were enrolled in our study from March 2014 to February 2015, with the average age of 65\u2009\u00b1\u20094.8\u2009years old. Modified electroconvulsive therapy (ECT) was performed in these patients after physical examinations and anesthesia procedures. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to assessing the efficacy of ECT, and Wechsler Memory Scale (WMS) and mini\u2010mental state examination (MMSE) were used to evaluate the memory ability and cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of efficacy was calculated as 67.44% after 4\u2009weeks of ECT treatment. Our results showed that HAMA and HAMD scores after 2\u2009weeks of ECT treatment were significantly lower than pretreatment, and the differences were more significant after 4\u2009weeks of ECT treatment. Compared with pretreatment, the scores of memory quotient and immediate memory of WMS decreased significantly after 1 week of treatment. However, these events were not be presented with the progress of treatment, except for after 2\u2009weeks of treatment. Our results demonstrated that compared with pretreatment, the scores of MMSE significantly increased after 4\u2009weeks of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ECT is an effective, well\u2010tolerated, and safe method for the treatment of older patients with refractory depression. ECT can be recommended for the treatment of these patients after conducting effective risk control of comorbid somatic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12411","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T03:55:08Z","timestamp":1597204508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of modified electroconvulsive therapy for the refractory depression in older patients"],"prefix":"10.1111","volume":"12","author":[{"given":"Xue","family":"Jiang","sequence":"first","affiliation":[{"name":"Psychiatric Intensive Care Unit (PICU) Wuhan Mental Health Center  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-8652","authenticated-orcid":false,"given":"Qin","family":"Xie","sequence":"additional","affiliation":[{"name":"Psychiatric Intensive Care Unit (PICU) Wuhan Mental 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