{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:26:15Z","timestamp":1778592375640,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471359"],"award-info":[{"award-number":["81471359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14411963400"],"award-info":[{"award-number":["14411963400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pacific Psychiatry"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that \u22654 hospitalizations (OR\u00a0=\u00a01.78, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), tobacco dependence (OR\u00a0=\u00a01.48, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), alcohol dependence (OR\u00a0=\u00a01.74, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013), and physical illness (OR\u00a0=\u00a01.89, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) were independently and significantly associated with a family history of mental disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/appy.12422","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T23:40:30Z","timestamp":1602718830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics of familial schizophrenia"],"prefix":"10.1111","volume":"13","author":[{"given":"Na","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Psychiatry Shanghai Tongji Hospital of Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai 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