{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:27:17Z","timestamp":1791012437230,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Symptoms of lactose intolerance are often attributed to lactose malabsorption but, as this relationship has not been demonstrated when a small dose of lactose similar to that contained in one cup of milk is ingested by intolerant patients, psychological factors may play a role in altered symptom perception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the hypothesis that the psychological profile influences the symptoms of lactose intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and two consecutive patients underwent a 15\u00a0g lactose hydrogen breath test to assess lactose malabsorption. The patients recorded the presence and severity of symptoms of lactose intolerance during the breath test using visual analogue scales. The psychological profile was assessed using a psychological symptom checklist, and health\u2010related quality of life by means of the short\u2010form health survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lactose malabsorption and intolerance were diagnosed in, respectively, 18% and 29% of the patients. The two conditions were not associated, and the severity of intolerance was even less in the patients with malabsorption. Multivariate logistic analysis showed that a high somatisation t\u2010score was significantly associated with lactose intolerance (odds ratio 4.184; 1.704\u201310.309); the effects of the other psychological variables and of lactose malabsorption were not statistically significant. Health\u2010related quality of life was significantly reduced in the patients with somatisation, but not in those with lactose malabsorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The symptoms of lactose intolerance during hydrogen breath testing at a low physiological lactose load, are unrelated to lactose malabsorption, but may reveal a tendency towards somatisation that could impair the quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12006","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T17:32:49Z","timestamp":1344015169000},"page":"660-669","source":"Crossref","is-referenced-by-count":52,"title":["Is the subjective perception of lactose intolerance influenced by the psychological profile?"],"prefix":"10.1111","volume":"36","author":[{"given":"C.","family":"Tomba","sequence":"first","affiliation":[{"name":"Post\u2010graduate School of Gastroenterology Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Baldassarri","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Post\u2010graduate School of Gastroenterology Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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