{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:43:09Z","timestamp":1785519789920,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Although most patients with gastro\u2010oesophageal reflux disease (\n                      <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\n                      ) benefit from proton pump inhibitor (\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      ) therapy, some experience only partial symptom relief.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To determine the prevalence of partial heartburn response to\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      s and its impact on health\u2010related quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four randomised, double\u2010blind studies in adults with reflux disease compared esomeprazole 40\u00a0mg\/day or 20\u00a0mg\/day with omeprazole 20\u00a0mg\/day, or esomeprazole 40\u00a0mg\/day with pantoprazole 40\u00a0mg\/day. Patients with heartburn on \u22654\u00a0days during the 1\u2010week recall period at baseline were included. Partial response was defined as heartburn on \u22653\u00a0days during the last treatment week and reduced heartburn frequency after 4\u00a0weeks of treatment compared with baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 2645 patients with non\u2010erosive reflux disease (mean age: 48.8\u00a0years; 54.4% women) and 3151 patients with reflux oesophagitis (mean age: 50.6\u00a0years; 37.1% women). At baseline, most patients reported heartburn on 5\u20137\u00a0days (non\u2010erosive reflux disease: 82.2%; reflux oesophagitis: 86.8%). Partial heartburn response occurred in 19.9% of patients with non\u2010erosive reflux disease and 14.0% with reflux oesophagitis. Defining partial response as heartburn on \u22652\u00a0days increased these rates to 26.2% and 19.3%, respectively; defining partial response as heartburn of moderate or severe intensity on \u22653\u00a0days decreased these rates to 6.4% and 5.3%, respectively. Nonresponse to\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      s was rare (non\u2010erosive reflux disease: 2.4%; reflux oesophagitis: 1.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Using our conservative definition, partial heartburn response to proton pump inhibitor therapy occurred in 14\u201320% of gastro\u2010oesophageal reflux disease patients, more commonly in non\u2010erosive reflux disease than in reflux oesophagitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12007","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T13:33:50Z","timestamp":1344000830000},"page":"635-643","source":"Crossref","is-referenced-by-count":66,"title":["Partial symptom\u2010response to proton pump inhibitors in patients with non\u2010erosive reflux disease or reflux oesophagitis \u2013 a\n                    <i>post hoc<\/i>\n                    analysis of 5796 patients"],"prefix":"10.1111","volume":"36","author":[{"given":"P.","family":"Bytzer","sequence":"first","affiliation":[{"name":"Department of Medical Gastroenterology K\u00f8ge University Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Veldhuyzen","family":"van Zanten","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of Alberta Edmonton AL Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mattsson","sequence":"additional","affiliation":[{"name":"AstraZeneca R&amp;D M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wernersson","sequence":"additional","affiliation":[{"name":"AstraZeneca R&amp;D M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03122.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.045"},{"key":"e_1_2_6_5_1","first-page":"CD002095","article-title":"Short\u2010term treatment with proton pump inhibitors, H2\u2010receptor antagonists and prokinetics for gastro\u2010oesophageal reflux disease\u2010like symptoms and endoscopy negative reflux disease","volume":"11","author":"van Pinxteren B","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_6_1","first-page":"CD003245","article-title":"Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease","volume":"2","author":"Donnellan C","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04406.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04358.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00343.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.03.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1209-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04774.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02085.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02368.x"},{"key":"e_1_2_6_15_1","first-page":"41","article-title":"Quality of life in reflux and dyspepsia patients. psychometric documentation of a new disease\u2010specific questionnaire (QOLRAD)","volume":"583","author":"Wiklund IK","year":"1998","journal-title":"Eur J Surg Suppl"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01306.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.146"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.01.022"},{"issue":"3","key":"e_1_2_6_19_1","first-page":"A267","article-title":"Problematic regurgitation despite potent acid suppression and heartburn relief in patients with non\u2010erosive reflux disease or reflux oesophagitis","volume":"60","author":"Kahrilas P","year":"2011","journal-title":"Gut"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04254.x"},{"key":"e_1_2_6_21_1","first-page":"9","article-title":"Esomeprazole in the treatment of patients with heartburn and other upper gastrointestinal symptoms, referred to primary care \u2013 results of the in\u2010practice evaluation program in Romania","volume":"14","author":"Diculescu M","year":"2005","journal-title":"Rom J Gastroenterol"},{"issue":"3","key":"e_1_2_6_22_1","first-page":"A267","article-title":"Does body mass index have an effect on symptom relief with esomeprazole in patients with reflux esophagitis or non\u2010erosive reflux disease?","volume":"60","author":"Nagy P","year":"2011","journal-title":"Gut"},{"issue":"2","key":"e_1_2_6_23_1","first-page":"A6","article-title":"Does body mass index have an effect on healing rates achieved with esomeprazole 40\u00a0mg in patients with reflux esophagitis?","volume":"58","author":"Nagy P","year":"2009","journal-title":"Gut"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01475.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-25"}],"container-title":["Alimentary Pharmacology &amp; 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