{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:58:03Z","timestamp":1776758283684,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,10]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The epidemiology of reactive gastropathy and its relationship with other conditions of the gastrointestinal tract associated with NSAID<\/jats:styled-content> use have not been evaluated.<\/jats:p><\/jats:sec>Aims<\/jats:title>To test the hypothesis that if reactive gastropathy shares common aetiological factors with these conditions, the analysis of a large cohort would unveil associations.<\/jats:p><\/jats:sec>Methods<\/jats:title>We queried a national pathology database for subjects with a diagnosis of reactive gastropathy; controls were patients with normal gastric biopsies. We also extracted diagnoses of H<\/jats:styled-content>. pylori<\/jats:italic> infection, intestinal metaplasia, duodenal lymphocytosis, duodenitis, ileitis, microscopic colitis and focal colitis.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 504\u00a0011 patients with gastric biopsies, 69\u00a0101 had oesophageal, 166\u00a0134 duodenal, 13\u00a0010 ileal and 83\u00a0334 colonic biopsies. Reactive gastropathy was diagnosed in 15.6% of patients, H<\/jats:styled-content>. pylori<\/jats:italic> infection in 10.3% and normal gastric mucosa in 16.3%. Reactive gastropathy was evenly distributed across the US<\/jats:styled-content> and increased from 2.0% in the first decade of life to\u00a0>20% in octogenarians. Compared with controls, reactive gastropathy was significantly associated with B<\/jats:styled-content>arrett's mucosa (OR<\/jats:styled-content> 1.21 95% CI<\/jats:styled-content> 1.16\u2013129); duodenitis (OR<\/jats:styled-content> 1.36; 95% CI<\/jats:styled-content> 1.28\u20131.44); duodenal intraepithelial lymphocytosis (OR<\/jats:styled-content> 1.25; 95% CI<\/jats:styled-content> 1.13\u20131.39); active ileitis (OR<\/jats:styled-content> 1.88; 95% CI<\/jats:styled-content> 1.47\u20132.40); focal active colitis (OR<\/jats:styled-content> 1.57; 95% CI<\/jats:styled-content> 1.33\u20131.86); and collagenous colitis (OR<\/jats:styled-content> 1.50; 95% CI<\/jats:styled-content> 1.12\u20132.03).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Reactive gastropathy, a common histopathological feature of the stomach, shows an age\u2010dependent rise and is associated with changes of the digestive tract believed to be caused by NSAID<\/jats:styled-content> use or duodenogastric reflux. However, a large fraction of reactive gastropathy remains unexplained; its frequent occurrence merits further efforts at elucidating its aetiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12031","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T01:41:13Z","timestamp":1346204473000},"page":"736-743","source":"Crossref","is-referenced-by-count":28,"title":["Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract"],"prefix":"10.1111","volume":"36","author":[{"given":"I.","family":"Maguilnik","sequence":"first","affiliation":[{"name":"Universidade do Rio Grande do Sul Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. L.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Miraca Research Institute Miraca Life Sciences Irving TX USA"},{"name":"University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Portland VA Medical Center Portland OR USA"},{"name":"Oregon Health & Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Genta","sequence":"additional","affiliation":[{"name":"Miraca Research Institute Miraca Life Sciences Irving TX USA"},{"name":"University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Dallas VA Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"907","article-title":"Alexis St Martin","volume":"80","author":"Bensley EH","year":"1959","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600813"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1111070"},{"key":"e_1_2_6_5_1","first-page":"674","article-title":"The histology of gastric mucosa in B II\u2010stomach","volume":"17","author":"Lechner HJ","year":"1979","journal-title":"Z Gastroenterol"},{"key":"e_1_2_6_6_1","first-page":"224","article-title":"Bile reflux after duodenal ulcer surgery. 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