{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:28Z","timestamp":1790802808798,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T00:00:00Z","timestamp":1347667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients treated with <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 inhibitors (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i) are at high risk of reactivation of latent tuberculosis (<jats:styled-content style=\"fixed-case\">LTB<\/jats:styled-content>). Prospective studies on monitoring of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> reactivation and\/or infection in this risk group are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To test the conversion and reversion rate of screening tests for latent TB serial tuberculin skin test (TST) and interferon\u2010\u03b3 release assay (IGRA) under ongoing TNFi therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retested consecutive patients with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> receiving <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i therapy for a minimum of 5\u00a0months for <jats:styled-content style=\"fixed-case\">LTB<\/jats:styled-content> using IGRA and TST. A detailed patient history and concomitant therapy were recorded for each subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median of 34.9\u00a0weeks (20.7\u2013177.7), <jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content> was retested in 184\/227 patients (81.1%; Crohn's disease <jats:italic>n\u00a0<\/jats:italic>=\u00a0139, ulcerative colitis <jats:italic>n<\/jats:italic>\u00a0=\u00a045) still under index <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i. <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> was available in 144\/184 subjects (78.2%). The majority of patients were <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i na\u00efve (147\/184, 79.9%). In a subgroup of patients who received isoniazid due to diagnosis of latent <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> at baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a032), 6\/13 patients (46.2%) with baseline positive <jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content> and 3\/22 patients (13.6%) with baseline positive <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> reverted to negative at retesting. In patients without diagnosis of <jats:styled-content style=\"fixed-case\">LTB<\/jats:styled-content> at baseline no permanent <jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content> conversion was observed, but there were 6\/144 (4.2%) <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> conversions from negative to positive. No single case of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> reactivation or infection was recorded during the observation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During treatment TNF\u2010\u03b1 inhibitors conversion was observed for tuberculin skin test, but not interferon\u2010\u03b3 release assay. As compared with tuberculin skin test, interferon\u2010\u03b3 release assay reverted in nearly half of isoniazid\u2010treated patients for latent tuberculosis. However, the fact that patients in whom the interferon\u2010\u03b3 release assay test result remained positive did not develop active tuberculosis during follow\u2010up questions the utility of interferon\u2010\u03b3 release assay as a monitoring tool during chemoprevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12037","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T11:22:26Z","timestamp":1347708146000},"page":"858-865","source":"Crossref","is-referenced-by-count":34,"title":["Retesting for latent tuberculosis in patients with inflammatory bowel disease treated with TNF\u2010\u03b1 inhibitors"],"prefix":"10.1111","volume":"36","author":[{"given":"P.","family":"Papay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Primas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Novacek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Division of Infectious Diseases Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Frantal","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Angelberger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mikulits","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dejaco","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kazemi\u2010Shirazi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Vogelsang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Reinisch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.322"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24632"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.118935"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.02.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02786.x"},{"key":"e_1_2_6_8_1","unstructured":"Data on file Abbott Analysis of Rheumatoid arthritis clinical trials 4\/2006. 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