{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:06:55Z","timestamp":1787893615553,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophilic oesophagitis (<jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content>) has evolved from a supposedly rare entity to one whose incidence rates are approaching that of inflammatory bowel disease. The factors responsible for this apparent increase in the incidence remain obscure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess various endoscopist and pathologist factors that might affect the frequency of EoE being detected in a well\u2010defined North American population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Increased endoscopist and pathologist awareness has contributed to the increased clinical recognition of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> were identified systematically using population\u2010based pathology and endoscopy databases from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2004 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2008 in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>algary, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anada (population 1.25\u00a0million). <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> frequency was estimated with time trend analysis. Characteristics of individual endoscopists (<jats:italic>n<\/jats:italic>\u00a0=\u00a045) were compared with diagnostic rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Crude population incidence of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> increased from 2.1 per 10<jats:sup>5<\/jats:sup> in 2004 to 11.0 per 10<jats:sup>5<\/jats:sup> in 2008: an annual increase of 39% (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). The frequency in men was 4.5 times higher than in women (95% CI: 3.51\u20135.76). In patients presenting with dysphagia oesophageal biopsy rates increased from 17.0% in 2004 to 41.3% of <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>s in 2008: an annual rise of 26% (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). On multivariate regression analysis, those endoscopists with higher biopsy rates were more likely to make the diagnosis of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.008). To include or exclude the diagnosis, typical histological features of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> were reported more often by pathologists in 2008 as compared to 2004 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01 &amp; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of eosinophilic oesophagitis continues to rise in the general population, in part due to increasing oesophageal biopsy rates and a more detailed histological evaluation of specimens. The biopsy rate of an endoscopist is an indicator for a higher diagnostic yield.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12053","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T06:25:21Z","timestamp":1348122321000},"page":"950-958","source":"Crossref","is-referenced-by-count":69,"title":["The rising incidence of eosinophilic oesophagitis is associated with increasing biopsy rates: a population\u2010based study"],"prefix":"10.1111","volume":"36","author":[{"given":"A. A. N.","family":"Syed","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Faculty of Medicine University of Calgary Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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