{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:19:22Z","timestamp":1791418762542,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incomplete resorption of fructose results in increased colonic hydrogen production and is a frequent cause of abdominal symptoms. The only treatment available is diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study whether orally administered xylose isomerase (<jats:styled-content style=\"fixed-case\">XI<\/jats:styled-content>), an enzyme that catalyses the reversible isomerisation of glucose and fructose, can decrease breath hydrogen excretion in patients with fructose malabsorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients received 25\u00a0g fructose in 100\u00a0mL water together with either placebo or <jats:styled-content style=\"fixed-case\">XI<\/jats:styled-content> capsules. Primary endpoint was the reduction in breath hydrogen excretion, as assessed by the area under the breath hydrogen curve over 4\u00a0h (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>). A secondary endpoint was the reduction in abdominal pain, bloating and nausea assessed on a visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>, range: 0\u201310). A <jats:italic>P<\/jats:italic> value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010five patients in whom fructose malabsorption had been diagnosed by positive breath hydrogen test within the previous year, were included in the study [15 males, 50 females; mean age 43.3 (s.d.\u00a0=\u00a014.4), range: 21\u201373\u00a0years]. The median <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> was 885\u00a0ppm\/240\u00a0min in the <jats:styled-content style=\"fixed-case\">XI<\/jats:styled-content> group compared to 2071\u00a0ppm\/240\u00a0min in the placebo group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00). Median scores for abdominal pain (0.7 vs. 1.3) and nausea (0.2 vs. 0.6), but not for bloating (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.053), were significantly improved after <jats:styled-content style=\"fixed-case\">XI<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) as compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral administration of xylose isomerase significantly decreased breath hydrogen excretion after ingestion of a watery fructose solution. Nausea and abdominal pain were significantly improved by xylose isomerase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12057","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T02:09:16Z","timestamp":1348538956000},"page":"980-987","source":"Crossref","is-referenced-by-count":34,"title":["Oral xylose isomerase decreases breath hydrogen excretion and improves gastrointestinal symptoms in fructose malabsorption \u2013 a double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"36","author":[{"given":"P.","family":"Komericki","sequence":"first","affiliation":[{"name":"Department of Environmental Dermatology and Venereology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Akkilic\u2010Materna","sequence":"additional","affiliation":[{"name":"Department of Environmental Dermatology and Venereology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Strimitzer","sequence":"additional","affiliation":[{"name":"Austrian Agency for Health and Food Safety Data collection statistics and risk assessment  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Weyermair","sequence":"additional","affiliation":[{"name":"Austrian Agency for Health and Food Safety Data collection statistics and risk assessment  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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