{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:07:10Z","timestamp":1767650830849},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data are available on the efficacy and safety of antiviral therapy in geriatric patients with chronic hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety of pegylated interferon (peg<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>) plus ribavirin (<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content>) therapy in geriatric <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010one geriatric patients (age \u226565\u00a0years; the elderly group) with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection and 91 gender\u2010 and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype\u2010matched middle\u2010aged patients (age 50\u201364\u00a0years; the younger group) were assigned to receive weekly peg<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> injection plus weight\u2010based oral <jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content> for 24\u00a0weeks. The on\u2010 and off\u2010treatment virological responses were evaluated for treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In intention\u2010to\u2010treat analysis, the sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) rate was substantially decreased in the elderly patients (elderly group vs. younger group, 40.7% vs. 61.5%, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). The <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> rate was significantly lower in geriatric patients than in middle\u2010aged patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype non\u20101 (54.3% vs. 82.9%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), but the difference was not significant with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 1 (32.1% vs. 48.2%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.083). Furthermore, the older patients infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype non\u20101 who achieved a rapid virological response had a similar <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> rate to that of the younger patients. The withdrawal rate was 13.2% in the elderly group and 7.7% in the younger group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with middle\u2010aged patients, the therapeutic efficacy of pegylated interferon plus ribavirin therapy is lower in hepatitis C virus\u2010infected geriatric patients with an acceptable withdrawal rate. Considering prolonged lifespan in geriatric patients, we recommend treating geriatric hepatitis C virus\u2010infected patients who have significant hepatic fibrosis and no other health problems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12112","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T08:08:40Z","timestamp":1352102920000},"page":"81-90","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy and safety of ribavirin plus pegylated interferon alfa in geriatric patients with chronic hepatitis <scp>C<\/scp>"],"prefix":"10.1111","volume":"37","author":[{"given":"C.\u2010C.","family":"Hu","sequence":"first","affiliation":[{"name":"Liver Research Unit Chang Gung Memorial Hospital Keelung Taiwan"},{"name":"Chang Gung University College of Medicine Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010L.","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Research Unit Chang Gung 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