{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:42:05Z","timestamp":1788306125642,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophilic oesophagitis (<jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content>) is a chronic inflammatory condition affecting both children and adults. Little is known about the natural history of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> in the transition from childhood into adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the prevalence of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> symptoms and impact of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> on quality of life among adults diagnosed with <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> during childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional study of <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> patients from the Children's Hospital of Philadelphia <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> registry. Patients \u226518\u00a0years diagnosed with <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> during childhood were administered validated dysphagia [Mayo Dysphagia Questionnaire (<jats:styled-content style=\"fixed-case\">MDQ<\/jats:styled-content>)\u201030] and Quality of Life (<jats:styled-content style=\"fixed-case\">PAGI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) questionnaires. Ongoing <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> treatments were ascertained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 140 EoE patients \u226518\u00a0years were identified; 53 completed all questions. Only 6 (11%) subjects had positive (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) or indeterminate (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) dysphagia scores. However, of 47 patients with negative scores, 18 (37%) reported ongoing difficulty swallowing. The mean <jats:styled-content style=\"fixed-case\">PAGI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> score was 4.58\/5. The dietary dimension score was 3.73\/5. Current pharmacological EoE treatments were topical steroids (3\/53) and interleukin\u20105 antagonists (3\/53). Additionally, 26\/53 (49%) were on <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy and 40\/53 (76%) were following allergy directed diets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of young adults diagnosed with <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> during childhood continue to require pharmacological treatment and\/or dietary modification for <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content>. A substantial proportion of this population experiences ongoing swallowing difficulties that a standard dysphagia questionnaire fails to capture. Dietary quality of life, but not total quality of life, appears to be adversely affected. These data suggest that <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> diagnosed during childhood remains a significant medical issue during early adulthood, and that better <jats:styled-content style=\"fixed-case\">EoE<\/jats:styled-content> symptom measurement instruments are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12119","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T08:08:51Z","timestamp":1352102931000},"page":"114-121","source":"Crossref","is-referenced-by-count":80,"title":["The natural history of eosinophilic oesophagitis in the transition from childhood to adulthood"],"prefix":"10.1111","volume":"37","author":[{"given":"P.","family":"Menard\u2010Katcher","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Marks","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Liacouras","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Spergel","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"},{"name":"Division of Allergy and Immunology Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010X.","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"},{"name":"Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. W.","family":"Falk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_6_1","first-page":"264","article-title":"Clinical presentation and treatment of pediatric patients with eosinophilic esophagitis","volume":"7","author":"Liacouras CA","year":"2011","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.94"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2007.09.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.09.74"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.06.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.994"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9246-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-126"},{"issue":"1","key":"e_1_2_7_17_1","first-page":"A63","article-title":"Predictive validity and responsiveness of the Mayo Dysphagia Questionnaire\u201030 for the outcome of dysphagia","volume":"136","author":"Francis DL","year":"2009","journal-title":"Gastroenterology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-8751-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00885-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.024"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61151-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.05.026"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.019"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00349-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04791.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01307.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T13:13:06Z","timestamp":1697634786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,5]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/apt.12119"],"URL":"https:\/\/doi.org\/10.1111\/apt.12119","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,5]]}}}